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Hirsutism (from Latin hirsutus = shaggy, hairy) is the excessive and increased
Causes
Hirsutism can be caused by either an increased level of
Growing evidence implicates high circulating levels of insulin in women to the development of hirsutism. This theory is consistent with the observation that obese (and thus presumably insulin resistant hyperinsulinemic) women are at high risk of becoming hirsute. Further, treatments that lower insulin levels will lead to a reduction in hirsutism.
It is speculated that insulin, at high enough concentration, stimulates the ovarian theca cells to produce androgens. There may also be an effect of high levels of insulin to activate the insulin-like growth factor-I (IGF-1) receptor in those same cells. Again, the result is increased androgen production.
The following may be some of the conditions that may increase a woman's normally low level of male hormones:
- Polycystic ovary syndrome
- Cushing's disease
- ovaries or adrenal gland (cancer)
- Certain medications
- Congenital adrenal hyperplasia
- Insulin resistance
- Stromal Hyperthecosis - in postmenopausal women
- Obesity: As there is peripheral conversion of estrogen to androgen in these patients, this is the same mechanism of PCOS
- Use of drugs like Tetrahydrogestrinone
Appearance and evaluation
Hirsutism affects women and sometimes men, since the rising of androgens causes a male pattern of body hair, sometimes excessive, particularly in locations where women normally do not develop terminal hair within their puberty (chest, abdomen, back and face). The medical term for excessive hair growth that affect both men and women is hypertrichosis.
One method of evaluating hirsutism is the
Treatment
Many women with unwanted hair seek methods of hair removal. However, the causes of the hair growth should be evaluated by a physician, who can conduct blood tests, pinpoint the specific origin of the abnormal hair growth, and advise on the treatment. One of the few treatments is the antiandrogen drug Spironolactone.
See also
- androgenic hair
- pubic hair
- hypertrichosis
- hair removal
- bearded lady
- trichophilia
References
Bibliography
- Ferriman D, Gallwey JD (1961). "Clinical assessment of body hair growth in women". J. Clin. Endocrinol. Metab. 21: 1440–7. PMID 13892577.
Notes
This article needs additional citations for verification. (January 2009) |
External links