Alclometasone
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Clinical data | |
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Trade names | Aclovate |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604021 |
Routes of administration | Topical |
ATC code | |
Legal status | |
Legal status |
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Pharmacokinetic data | |
Bioavailability | 3% systemically (topical) |
Metabolism | Hepatic |
Onset of action | Eczema: 5.3 - 13.9 days; Psoriasis: 6.7 - 14.8 days [1] |
Identifiers | |
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JSmol) | |
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Alclometasone is a synthetic corticosteroid for topical dermatologic use, possessing anti-inflammatory, antipruritic, and vasoconstrictive properties.[2]
The
GlaxoSmithKline
as a topical cream and ointment. However, generic versions of the drug are available.
Medical uses
Alclometasone cream and ointment are indicated for the relief of corticosteroid-responsive dermatoses, including:
- atopic dermatitis
- eczema
- psoriasis
- allergic dermatitis
- contact dermatitis
- actinic dermatitis
- kiss-type allergy
- skin itch
Alclometasone may be used on sensitive skin sites (face, skinfolds); in pediatric patients 1 year or older and in geriatric patients.
Contraindications
- hypersensitivity to alclometasone or any of ingredients in pharmaceutical forms
- cutaneous tuberculosis
- chicken pox
- perioral dermatitis
- acne
- rosacea
- open wounds
- trophic ulcers
- viral infection of skin
- skin manifestations of syphilis
Side effects
Adverse reactions (sometimes, less than 1-2% cases) include:
- burning
- itching
- erythema
- skin reddening
- xerodermia
- skin irritation
- acne
- hypopigmentation
- prickly heat
- folliculitis
- white atrophy
- hypertrichosis
- reinfection of skin
Pharmacology
Alclometasone induces the production of lipocortins, formally known as
leukotrienes
, can't be produced.
Alclometasone also inhibits the release of pro-inflammatory mediators from leukocytes (e.g.,
).Formulations
Alclometasone as Aclovate is supplied in:
- Cream; Topical; 0.05%
- Ointment; Topical; 0.05%
References
- ^ "Alclometasone - Professional Patient Advice". Drugs.com. Retrieved 29 December 2017.
- ^ "Alclometasone - FDA Prescribing Information". Drugs.com. Retrieved 29 December 2017.