Medrysone

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Medrysone
Clinical data
Trade namesHMS, Medrocort, others
Other namesNSC-63278; Hydroxymethylprogesterone; Methylhydroxyprogesterone; Hydroxymesterone; 6α-Methyl-11β-hydroxyprogesterone; 6α-Methyl-11β-hydroxypregn-4-ene-3,20-dione
AHFS/Drugs.comMicromedex Detailed Consumer Information
MedlinePlusa606003
Routes of
administration		Eye drops
ATC code
Legal status
Legal status
  • US: Discontinued
Identifiers
  • (6S,8S,9S,10R,11S,13R,14S,17S)- 17-acetyl-11-hydroxy-6,10,13-trimethyl-1,2,6,7,8,9,
    11,12,14,15,16,17- dodecahydrocyclopenta[a] phenanthren-3-one
JSmol)
  • C[C@H]1C[C@H]2[C@@H]3CC[C@@H]([C@]3(C[C@@H]([C@@H]2[C@@]4(C1=CC(=O)CC4)C)O)C)C(=O)C
  • InChI=1S/C22H32O3/c1-12-9-15-17-6-5-16(13(2)23)22(17,4)11-19(25)20(15)21(3)8-7-14(24)10-18(12)21/h10,12,15-17,19-20,25H,5-9,11H2,1-4H3/t12-,15-,16+,17-,19-,20+,21-,22+/m0/s1 ☒N
  • Key:GZENKSODFLBBHQ-ILSZZQPISA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Medrysone (

synthetic glucocorticoid that is or has been used in the treatment of inflammatory eye diseases.[1][2][3] It has been discontinued in the United States.[4] Although it is very similar in structure to progesterone,[5] neither progestogenic nor androgenic activity has been demonstrated for or attributed to medrysone.[6][7][8]

Environmental presence

In 2021, medrysone was one of the 12 compounds identified in sludge samples taken from 12

estrogenic activity in in vitro. [9]

See also

References

  1. ISBN 978-1-4757-2085-3
    .
  2. ISBN 978-3-88763-075-1
    .
  3. ISBN 978-0-7514-0499-9
    .
  4. ^ "HMS - FDA prescribing information, side effects and uses".
  5. PMID 5764682
    .
  6. PMID 5327794
    .
  7. S2CID 37303359
    .
  8. PMID 5554878
    .
  9. PMID 33909413
    .
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