Chlorphentermine

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Chlorphentermine
Skeletal formula
Ball-and-stick model of chlorphentermine
Clinical data
Other namesp-Chloro-α,α-dimethylphenethylamine
Routes of
administration		Oral, Insufflated, Rectal
ATC code
Legal status
Legal status
Pharmacokinetic data
Elimination half-life40 hours
ExcretionRenal
Identifiers
  • 1-(4-chlorophenyl)-2-methylpropan-2-amine
JSmol)
  • Clc1ccc(cc1)CC(N)(C)C
  • InChI=1S/C10H14ClN/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6H,7,12H2,1-2H3 checkY
  • Key:ZCKAMNXUHHNZLN-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Chlorphentermine (trade names Apsedon, Desopimon, Lucofen) is a serotonergic appetite suppressant of the amphetamine family. Developed in 1962, it is the 4-chloro derivative of the better known appetite suppressant phentermine,[2] which is still in current use.

Chlorphentermine acts as a highly selective

diethylpropion which have been more widely abused. It is no longer used due mainly to safety concerns, as it has a serotonergic effects profile similar to other withdrawn appetite suppressants such as fenfluramine and aminorex which were found to cause pulmonary hypertension and cardiac fibrosis following prolonged use.[4]

The plasma half-life is about five days.[5] It was withdrawn from the market in the UK in 1974.[5]

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. PMID 13903304
    .
  3. S2CID 15573624
    .
  4. PMID 10458725
    .
  5. ^
    S2CID 25704474
    .
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