Dermatan sulfate
ECHA InfoCard 100.042.305 | | |
| Chemical and physical data | ||
|---|---|---|
| Formula | C14H21NO15S | |
| Molar mass | 475.37 g·mol−1 | |
  (what is this?) (verify) | ||
Dermatan sulfate is a
lungs
.
It is also referred to as
N-acetyl galactosamine (GalNAc) and iduronic acid (IdoA). These repeating units are sulfated at a variety of positions.[2] Dermatan sulfate is a component of the compound sulodexide.[3]
Function
Dermatan sulfate may have roles in
Pathology
Dermatan sulfate accumulates abnormally in several of the mucopolysaccharidosis disorders.
An excess of dermatan sulfate in the
left heart
failure if untreated.
See also
References
- ^ PMID 12213784.
- ^ "Dermatan sulfate".
- PMID 22282689.
Sulodexide is a highly purified glycosaminoglycan (GAG) obtained from porcine digestive mucosa and is composed of a mixture of 80% heparan sulfate (an electrophoretically fast moving fraction with a low molecular weight of 7000 Da and affinity for antithrombin III) and 20% dermatan sulfate with a high molecular weight (25,000 Da) and affinity for the heparin II cofactor.
External links
- Dermatan+sulfate at the U.S. National Library of Medicine Medical Subject Headings (MeSH)