Elinogrel

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Elinogrel
Clinical data
Other namesPRT-060128
Routes of
administration		By mouth, IV
ATC code
  • None
Legal status
Legal status
  • Development terminated
Pharmacokinetic data
MetabolismMainly unchanged, ~15% N-demethylation[1]
ExcretionUrine, faeces
Identifiers
  • N-[(5-Chlorothiophen-2-yl)sulfonyl]-N′-{4-[6-fluoro-7-(methylamino)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl]phenyl}urea
JSmol)
SMILES
  • CNC1=C(C=C2C(=C1)NC(=O)N(C2=O)C3=CC=C(C=C3)NC(=O)NS(=O)(=O)C4=CC=C(S4)Cl)F
  • InChI=1S/C20H15ClFN5O5S2/c1-23-15-9-14-12(8-13(15)22)18(28)27(20(30)25-14)11-4-2-10(3-5-11)24-19(29)26-34(31,32)17-7-6-16(21)33-17/h2-9,23H,1H3,(H,25,30)(H2,24,26,29)
  • Key:LGSDFTPAICUONK-UHFFFAOYSA-N

Elinogrel (

intravenously for acute treatment and orally for long-term treatment.[3]
Development was terminated in 2012.

History

The substance was originally developed by Portola Pharmaceuticals, with Phase II clinical trials conducted around 2008–2011.[4] In February 2009, Novartis bought worldwide rights to develop it further, intending to conduct Phase III studies and commercialise the drug.[5] The development of the drug was terminated in January 2012 by Novartis.[6]

References

  1. PMID 20050853
    .
  2. ^ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List 63" (PDF). World Health Organization. pp. 50–1. Retrieved 1 December 2016.
  3. S2CID 79785538
    .
  4. PMID 22160013
    .
  5. ^ "Novartis gains worldwide rights to elinogrel, a Phase II anti-clotting compound with potential to reduce risk of heart attack". Insciences. Archived from the original on 2014-07-14.
  6. ^ "Novartis drops elinogrel outright". BioPortfolio. Archived from the original on 2012-07-29.
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