Alteplase

Alteplase, sold under the brand name Activase among others, is a biosynthetic form of human

It is on the World Health Organization's List of Essential Medicines.^[8]

Medical uses

Alteplase is

In adults diagnosed with acute ischemic stroke, thrombolytic treatment with alteplase is the standard of care.[10]^[11] Administration of alteplase is associated with improved functional outcomes and reduced incidence of disability.^[12] Alteplase used in conjunction with mechanical thrombectomy is associated with better outcomes.^[13][14]

Pulmonary embolism

As of 2019, alteplase is the most commonly used medication to treat pulmonary embolism (PE).^[15] Alteplase has a short infusion time of 2 hours and a half-life of 4–6 minutes.^[15] Alteplase has been approved by the FDA, and treatment can be done via systemic thrombolysis or catheter-directed thrombolysis.^[15][16]

Systemic thrombolysis can quickly restore right ventricular function, heart rate, and blood pressure in patients with acute PE.^[17] However, standard doses of alteplase used in systemic thrombolysis may lead to massive bleeding, such as intracranial hemorrhage, particularly in older patients.^[15] A systematic review has shown that low-dose alteplase is safer than and as effective as the standard amount.^[18]

Blocked catheters

Alteplase can be used in small doses to clear blood clots that obstruct a catheter, reopening the catheter so it can continue to be used.^[3][12] Catheter obstruction is commonly observed with a central venous catheter.^[19] Currently, the standard treatment for catheter obstructions in the United States is alteplase administration.^[6] Alteplase is effective and low risk for treating blocked catheters in adults and children.^[6][19] Overall, adverse effects of alteplase for clearing blood clots are rare.^[20] Novel alternatives to treat catheter occlusion, such as tenecteplase, reteplase, and recombinant urokinase, offer the advantage of shorter dwell times than alteplase.^[19]

Contraindications

A person should not receive alteplase treatment if testing shows they are not suffering from an acute ischemic stroke or if the risks of treatment outweigh the likely benefits.^[10] Alteplase is contraindicated in those with bleeding disorders that increase a person's tendency to bleed and in those with an abnormally low platelet count.^[14] Active internal bleeding and high blood pressure are additional contraindications for alteplase.^[14] The safety of alteplase in the pediatric population has not been determined definitively.^[14] Additional contraindications for alteplase when used specifically for acute ischemic stroke include current intracranial hemorrhage and subarachnoid hemorrhage.^[21] Contraindications for use of alteplase in people with a STEMI are similar to those of acute ischemic stroke.^[9] People with an acute ischemic stroke may also receive other therapies including mechanical thrombectomy.^[10]

Adverse effects

Given that alteplase is a thrombolytic medication, a common adverse effect is bleeding, which can be life-threatening.^[22] Adverse effects of alteplase include symptomatic intracranial hemorrhage and fatal intracranial hemorrhage.^[22]

Alteplase binds to

Plasminogen activator inhibitor 1 stops alteplase activity by binding to it and forming an inactive complex, which is removed from the bloodstream by the liver.^[7] Fibrinolysis by plasmin is extremely short-lived due to plasmin inhibitors, which inactivate and regulate plasmin activity.^[7]

History

In 1995, a study by the National Institute of Neurological Disorders and Stroke showed the effectiveness of administering intravenous alteplase to treat ischemic stroke.^[23] This sparked a medical paradigm shift as it redesigned stroke treatment in the emergency department to allow for timely assessment and therapy for ischemic stroke patients.^[23]

Society and culture

Alteplase was added to the World Health Organization's List of Essential Medicines in 2019, for use in ischemic stroke.^[24][25]

Legal status

In May 1987, the United States FDA requested additional data for the drug rather than approve it outright, causing Genentech stock prices to fall by nearly one quarter. The decision was described as a surprise to the company as well as many cardiologists and regulators,^[26] and it generated significant criticism of the FDA, including from The Wall Street Journal editorial board.^[27][28]

After results from two additional trials were obtained,

The cost of alteplase in the United States increased by 111% between 2005 and 2014, despite there being no proportional increase in the costs of other prescription drugs.[31] However, alteplase continues to be cost-effective.^[31]

Brand names

Alteplase is marketed as Actilyse, Activase, and Cathflo or Cathflo Activase.^{[2][3][32][33]}

Controversies

Alteplase is extremely underused in

There may be citation bias in the literature on alteplase in ischemic stroke, as studies reporting positive results for tissue plasminogen activator are more likely to be cited in following studies than those reporting negative or neutral results.[35]

There is a sex difference in the use of intravenous tissue plasminogen activator, as it is less likely to be used for women with acute ischemic stroke than men.^[36] However, this difference has been improving since 2008.^[36]

References