Diiodohydroxyquinoline

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Diiodohydroxyquinoline
Skeletal formula of diiodohydroxyquinoline
Ball-and-stick model of the diiodohydroxyquinoline molecule
Names
Preferred IUPAC name
5,7-Diiodoquinolin-8-ol
Other names
Diquinol, iodoxin, diiodoquin, amebaquin
Identifiers
3D model (
JSmol
)
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard
 100.001.362 Edit this at Wikidata
KEGG
MeSH Iodoquinol
UNII
  • InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H ☒N
    Key: UXZFQZANDVDGMM-UHFFFAOYSA-N ☒N
  • InChI=1/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
    Key: UXZFQZANDVDGMM-UHFFFAOYAF
  • C1=CC2=C(C(=C(C=C2I)I)O)N=C1
Properties
C9H5I2NO
Molar mass 396.951
Pharmacology
G01AC01 (WHO)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒N verify (what is checkY☒N ?)

The

INN), or iodoquinol (USAN), brand name Diodoquin, can be used in the treatment of amoebiasis.[1]

It is poorly absorbed from the

ferrous ions essential for metabolism.[2]

It was discovered by Adco Co. and introduced as diiodohydroxyquinoline.[3]

Susceptibility of Dientamoeba fragilis has been measured.[4]

Iodoquinol is an amebicide used against Entamoeba histolytica, and it is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. The full mechanism of action is unknown. Iodoquinol is used for diseases caused by moderate intestinal amebiasis.

Diiodohydroxyquinoline enhances zinc absorption in the zinc deficiency disorder acrodermatitis enteropathica, probably because it acts as a zinc ionophore.[5]

See also

References

  1. PMID 2493578
    .
  2. PMID 24533282
    .
  3. ISBN 9780080947266
    .
  4. PMID 8067755
    .
  5. PMID 375935
    .
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