Tinidazole
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Trade names | Fasigyn, Simplotan, Tindamax |
AHFS/Drugs.com | Monograph |
MedlinePlus | a604036 |
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Pharmacokinetic data | |
Protein binding | 12% |
Metabolism | Liver (CYP3A4) |
Elimination half-life | 12–14 hours |
Excretion | Urine (20–25%), feces (12%) |
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Tinidazole, sold under the brand name Tindamax among others, is a medication used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of anaerobic amoebic and bacterial infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.[2]
It is on the World Health Organization's List of Essential Medicines.[3]
Medical uses
Tinidazole may be a therapeutic alternative in the setting of metronidazole intolerance. Tinidazole is used to treat Helicobacter pylori, Amoebic dysentery, Giardia and Trichomonas vaginalis.[4]
Side effects
Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.[medical citation needed]
Half-life
Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.[medical citation needed]
References
- FDA. Retrieved 22 Oct 2023.
- ISBN 3527306730.
- hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- PMID 8444678.