Phosphorylcholine

Source: Wikipedia, the free encyclopedia.
This article is about the functional group derived from phosphocholine. For the class of phospholipids that incorporate choline as a headgroup, see phosphatidylcholine.

Phosphorylcholine (abbreviated ChoP) is the

autoantibodies.[3]

Thrombus-resistant stents

In

thrombogenicity.[5] Until 2002, over 120,000 phosphorylcholine-coated stents have been implanted in patients with no apparent deleterious effect in the long term compared to bare metal stent technologies.[6]

Phosphorylcholine polymer-based drug-eluting stents

Drug-eluting stents (DES) are used by interventional cardiologists, operating on patients with

balloon angioplasty. This will dilate the diameter of the coronary artery and keep it fixed in this phase so that more blood flows through the artery without the risk of blood clots (atherosclerosis).[7]

Phosphorylcholine is used as the polymer-based coating of a DES because its molecular design improves surface biocompatibility and lowers the risk of causing inflammation or

biomimicry, or the practice of using polymers that occur naturally in biology, provides a coating with minimal thrombus deposition and no adverse clinical effect on late healing of the arterial vessel wall. Not only is the coating non-thrombogenic, but it also exhibits other features that should be present when applying such a material to a medical device for long-term implantation. These include durability, neutrality to the chemistry of the incorporated drug and ability for sterilization using standard methods which do not affect drug structure or efficiency[citation needed
]

See also

References

  1. OCLC 432406854
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  2. S2CID 37626179
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  3. ISBN 978-0-7817-6519-0
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  4. ^ "Alpha-GPC vs Choline Bitartrate". Retrieved 2023-12-05.
  5. ^ J.A. Hayward and D. Chapman, Biomembrane surfaces as models for polymer design: the potential for haemocompatibility, Biomaterials 5 (1984), pp. 135–142. https://doi.org/10.1016/0142-9612(84)90047-4 Retrieved on 2009-02-09
  6. ^ A.L. Lewis, L.A. Tolhurst and P.W. Stratford, Analysis of a phosphorylcholine-based polymer coating on a coronary stent pre- and post-implantation, Biomaterials 23 (2002), pp. 1697–1706. https://dx.doi.org/10.1016/S0142-9612(01)00297-6 Retrieved on 2009-02-09
  7. ^ A. L. Lewis, P. W. Stratford, A. L. Lewis, R. T. Freeman, L. Hughes, R. P. Redman, L. A. Tolhurst and T. A. Vick, Abstracts of UKSB 1st Annual Conference, July 2000. https://doi.org/10.1023%2FA%3A1012803503667 Retrieved on 2009-02-09

External links