Ethoxzolamide

Ethoxzolamide

Clinical data
ATC code	None
Pharmacokinetic data
Protein binding	~89%
Elimination half-life	2.5–5.5 hours
Identifiers
IUPAC name 6-Ethoxy-1,3-benzothiazole-2-sulfonamide
JSmol)	Interactive image
SMILES O=S(=O)(c1nc2ccc(OCC)cc2s1)N
InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13) Y Key:OUZWUKMCLIBBOG-UHFFFAOYSA-N Y
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Ethoxzolamide (alternatively known as ethoxyzolamide) is a

Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Mechanism of action

Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems.

Synthesis

See also

• Dimazole
• Dithiazanine iodide

References