Potassium channel opener
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A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels.
Examples
Some examples include:
- Diazoxide[1] vasodilator used for hypertension, smooth muscle relaxing activity
- Minoxidil[2] vasodilator used for hypertension, also used to treat hair loss
- Nicorandil[3] vasodilator used to treat angina
- Pinacidil[4]
- Retigabine,[5][6] an anticonvulsant
- Flupirtine, analgesic with muscle relaxant and anticonvulsant properties
| Class | Subclasses | Activators |
|---|---|---|
| Calcium-activated
6 P
|
[citation needed]
| |
Inwardly rectifying
2 P
|
|
[citation needed]
|
|
[citation needed]
| |
|
[citation needed] | |
Tandem pore domain
4 P
|
[citation needed] | |
| Voltage-gated
6 P
|
|
See also
References
- PMID 16159820.
- S2CID 6948410.
- PMID 18981577.
- ]
- PMID 9384239.
- S2CID 11112809.
- ^ S2CID 9358238.
- ^ S2CID 12759521.
- ^ PMID 9628867.
- S2CID 9682396.
- S2CID 22656809.
- S2CID 21219622.
- S2CID 20181576.
- S2CID 23092576.
- S2CID 45487917.
- PMID 18590620.
- PMID 31568714.
XEN1101 is a novel positive allosteric modulator ("opener") of the potassium channel KCNQ2/3 (Kv7.2/7.3) currently being developed by Xenon Pharmaceuticals Inc. for the treatment of focal epilepsy.
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