Channel modulator
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Type of drug which modulates ion channels
A channel modulator, or ion channel modulator, is a type of drug which modulates ion channels. They include channel blockers and channel openers.[1]
Direct modulators
Ion channels are typically categorised by gating mechanism and by the ion they conduct. Note that an ion channel may overlap between different categories. Some channels conduct multiple ion currents and some are gated by multiple mechanisms.
Examples of targets for modulators include:
- Calcium channel: see also Calcium channel blocker, Calcium channel opener
- Potassium channel: see also Potassium channel blocker, Potassium channel opener
- Sodium channel: see also Sodium channel blocker, Sodium channel opener
- Chloride channel: see also Chloride channel blocker, Chloride channel opener
- Transient receptor potential channel
Ligand gated ion channels
- 5-HT3: see also 5-HT3 antagonist,
- GABAA receptor: see also GABA receptor agonist, GABA receptor antagonist
- Glutamate receptor: see also Excitatory amino acid receptor agonist, Excitatory amino acid receptor antagonist, Ionotropic glutamate receptor, Ampakine, NMDA receptor antagonist
- )
Ion channels gated by other mechanisms (e.g. light gated and
mechanosensitive ion channels
). These types of channels can also be pharmacologically modulated. For lists of the substances that pharmacologically modulate them, see their respective articles.
Indirect modulators
Ion channels can also be modulated indirectly. For example with
releasing agents
.
See also
- Enzyme modulator
- Receptor modulator
- Transporter modulator
References
- PMID 15081958.
Types |
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Classes |
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VGKCsTooltip Voltage-gated potassium channels
Blockers |
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Activators |
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IRKsTooltip Inwardly rectifying potassium channel
Blockers |
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Activators |
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Blockers |
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Activators |
K2PsTooltip Tandem pore domain potassium channel
Blockers |
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Activators |
VGSCsTooltip Voltage-gated sodium channels
Blockers |
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Activators |
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Blockers | |
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Activators |
Blockers |
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CaCCsTooltip Calcium-activated chloride channel
Blockers |
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Activators |
Blockers | |
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Activators |
Blockers |
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TRPs Tooltip Transient receptor potential channels |
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LGICs Tooltip Ligand gated ion channels |
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TRPA |
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TRPC |
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TRPM |
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TRPML |
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TRPP |
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TRPV |
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See also: Receptor/signaling modulators • Ion channel modulators |
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