Substituted piperazine
Substituted piperazines are a class of
scientific research.[2]
List of substituted piperazines
Benzylpiperazines
-
1-Benzylpiperazine(BZP)
-
1-Methyl-4-benzylpiperazine(MBZP)
-
1,4-Dibenzylpiperazine(DBZP)
-
3,4-Methylenedioxy-1-benzylpiperazine(MDBZP)
-
4-Bromo-2,5-dimethoxy-1-benzylpiperazine(2C-B-BZP)
-
Methoxypiperamide (MeOP, MEXP) ((4-methoxyphenyl)(4-methylpiperazin-1-yl)methanone)
-
Sunifiram (1-benzoyl-4-propanoylpiperazine)
-
3-Methylbenzylpiperazine (3-MeBZP)
-
Befuraline
(also produces benzylpiperazine as a metabolite) -
Fipexide
(also produces substituted benzylpiperazine as a metabolite) -
Piberaline
(also produces benzylpiperazine as a metabolite)
Phenylpiperazines
ortho-Substituted
- 2-Chlorophenylpiperazine (oCPP)
- 2-Methylphenylpiperazine(oMPP)
- 2-Methoxyphenylpiperazine (oMeOPP)
- Vortioxetine
Enpiprazole is known to produce oCPP as a metabolite.
Enciprazine was initially anticipated to produce oMeOPP as a metabolite, but this turned out not to be the case.
meta-Substituted
- 3-Chlorophenylpiperazine(mCPP)
- 3-Methoxyphenylpiperazine (mMeOPP)
- 3-Trifluoromethylphenylpiperazine(TFMPP)
- 1-(3-Chlorophenyl)-4-(2-phenylethyl)piperazine (3C-PEP)
Trazodone, nefazodone, mepiprazole, and others produce mCPP as a metabolite.
para-Substituted
- 4-Chlorophenylpiperazine(pCPP)
- 4-Fluorophenylpiperazine(pFPP)
- 4-Methylphenylpiperazine (pMPP)
- 4-Methoxyphenylpiperazine(MeOPP)
- 4-Nitrophenylpiperazine (pNPP)
- 4-Trifluoromethylphenylpiperazine (pTFMPP)
Multiple substitutions
-
2,3-Dichlorophenylpiperazine (2,3-DCPP)
-
3,4-Dichlorophenylpiperazine(3,4-DCPP)
- 2,3-Methylphenylpiperazine (DMPP)
- 3-Trifluoromethyl-4-chlorophenylpiperazine (TFMCPP)
Others
- 1-Phenylpiperazine(PP)
Other arylpiperazines
- 1-(1-Naphthyl)piperazine(1-NP)
- 1-(2-Pyrimidinyl)piperazine(1-PP)
- ORG-12962 (1-(5-trifluoromethyl-6-chloropyridin-2-yl)piperazine)
- Quipazine (2-piperazin-1-ylquinoline)
Many azapirones such as buspirone, gepirone, and tandospirone produce 1-PP as a metabolite.
See also
- Substituted α-alkyltryptamine
- Substituted amphetamine
- Substituted cathinone
- Substituted methylenedioxyphenethylamine
- Substituted phenethylamine
- Substituted phenylmorpholine
- Substituted tryptamine
References
- S2CID 85385527.
- .