Geographic tongue

Source: Wikipedia, the free encyclopedia.
Geographic tongue
Oral and Maxillofacial Surgery, Dermatology
SymptomsBurning sensation (rare)
CausesUnknown
Diagnostic methodVisual examination
Differential diagnosisOral lichen planus, erythematous candidiasis, leukoplakia, glossitis, and chemical burns
PreventionNone
TreatmentReassurance, time
MedicationNone
Frequency2-3%
DeathsNone

Geographic tongue, also known by several other terms,

lingual papillae) which migrate over time. The name comes from the map-like appearance of the tongue,[8] with the patches resembling the islands of an archipelago.[2] The cause is unknown, but the condition is entirely benign (importantly, it does not represent oral cancer
), and there is no curative treatment. Uncommonly, geographic tongue may cause a burning sensation on the tongue, for which various treatments have been described with little formal evidence of efficacy.

Signs and symptoms

The appearance of geographic tongue is variable from one person to the next and changes over time. The bottom image shows fissured tongue combined with geographic tongue. It is common for these two conditions to coexist.

In health, the dorsal surface of the tongue is covered in tuft-like projections called

taste buds), which give the tongue an irregular surface texture and a white-pink color. Geographic tongue is characterized by areas of atrophy and depapillation (loss of papillae), leaving an erythematous (darker red) and smoother surface than the unaffected areas. The depapillated areas are usually well-demarcated,[4] and bordered by a slightly raised, white, yellow or grey, serpiginous (snaking) peripheral zone.[9] A lesion of geographic tongue may start as a white patch before the depapillation occurs.[4] In certain cases there may be only one lesion, but this is uncommon;[4] the lesions will typically occur in multiple locations on the tongue and coalesce over time to form the typical map-like appearance. The lesions usually change in shape and size, and migrate to other areas, sometimes within hours.[10] The condition may affect only part of the tongue, with a predilection for the tip and the sides of the tongue,[4] or the entire dorsal surface at any one time. The condition goes through periods of remission and relapse. Loss of the white peripheral zone is thought to signify periods of mucosal healing.[9]

There are usually no symptoms other than the unusual appearance of the tongue, but in some cases persons may experience pain or burning, e.g. when eating hot, acidic, spicy or other kinds of foods (e.g. cheese, tomatoes, fruit).[1][10] Where there is a burning symptom, other causes of a burning sensation on the tongue are considered, such as oral candidiasis.[11]

Causes

The cause is unknown.

Vitamin B2 deficiency (ariboflavinosis) can cause several signs in the mouth, possibly including geographic tongue,[14] although other sources state that geographic tongue is not related to nutritional deficiency.[2] Fissured tongue often occurs simultaneously with geographic tongue,[1] and some consider fissured tongue to be an end stage of geographic tongue.[9]

In the past, some research suggested that geographic tongue was associated with

nickel sulphate.[15] Some studies have reported a link between geographic tongue and psoriasis,[16] although 90% of children who are diagnosed with geographic tongue do not develop psoriasis.[13] Again however, modern research studies do not support any link between psoriasis and geographic tongue.[12] Lesions that are histologically indistinguishable from geographic tongue may also be diagnosed in reactive arthritis (arthritis, uveitis/conjunctivitis and urethritis).[9]

Predisposing Factors

Geographic tongue (GT) is a lesion with an unknown origin. However, it has been reported more frequently in people with psoriasis, history of allergies, asthma and rhinitis. Studies have also suggested that psychological/psychiatric factors, diabetes, gastrointestinal diseases and haematological disorders may predispose to GT however, more studies with a larger cohort are needed to determine if GT could be an oral manifestation of a systemic disease.

There is strong evidence to support a high prevalence of celiac disease and iron-deficiency anaemia in patients with GT. Oral candidiasis and caries are commonly reported in patients with GT, however this can be explained by saliva of a lower pH which will promote the cariogenic process.

Most common areas in which GT can be found include; the lateral border of the tongue, followed by the anterior dorsum of the tongue and ventral surface.[17]

Diagnosis

Diagnosis of Geographic Tongue (GT) mainly relies on clinical, intraoral findings. As GT is usually asymptomatic in the mouth it does not require treatment. A differential diagnosis between oral candidiasis and GT, two similar looking conditions, can be established through a careful and thorough examination. GT is a keratotic lesion which can be described as a round or irregular shaped white plaque, cannot be scraped off and is normally self-resolving.[18] These lesions are known to reoccur within variable periods. Although rare, cytological techniques and biopsies can be done to aid in a clinical diagnosis. The cytological description can define the disease due to its inflammatory characteristics, with its main characteristic being nuclear demarcation. Furthermore, it is important to be aware that GT may be related to other extraoral and intraoral conditions.

The

Atrophic glossitis is usually distinguished from benign migratory glossitis on the basis of the migrating pattern of the lesions and the presence of a whitish border, features which are not present in atrophic glossitis, which instead shows lesions which enlarge rather than migrate.[19] Rarely, blood tests may be required to distinguish from glossitis associated with anemia or other nutritional deficiencies.[10] Since the appearance and the history of the condition (i.e. migrating areas of depapillation) are so striking, there is rarely any need for biopsy.[11]
When biopsy is taken, the histopathologic appearance is quite similar to psoriasis:

  • Hyperparakeratosis.
  • Acanthosis
    .
  • Subepithelial
    T lymphocyte
    inflammatory infiltrate.
  • Migration of neutrophilic granulocytes into the
    Munro's microabscesses described in pustular psoriasis.[9]

Classification

Geographic tongue could be considered to be a type of glossitis. It usually presents only on the dorsal 2/3 and lateral surfaces of the tongue,[1] but less commonly an identical condition can occur on other mucosal sites in the mouth, such as the ventral surface (undersurface) of the tongue, mucosa of the cheeks or lips, soft palate or floor of mouth; usually in addition to tongue involvement.[11] In such cases, terms such as stomatitis erythema migrans,[11] ectopic geographic tongue,[11] areata migrans,[7] geographic stomatitis,[9] or migratory stomatitis are used instead of geographic tongue. Beside the differences in locations of presentation inside the oral cavity and prevalence among the general population, in all other aspects of clinical significance, symptoms, treatment, and histopathologic appearance, these two forms are identical.

This condition is sometimes termed (oral) erythema migrans, but this has no relation to the more common use of the term erythema migrans (erythema chronicum migrans), to describe the appearance of skin lesions in Lyme disease and southern tick-associated rash illness.[10]

Treatment

Geographic tongue (GT) also termed benign migratory glossitis usually presents without symptoms and due to a lack of reliable evidence, researchers can not identify a specific treatment for the condition. It is currently suggested that patients are given reassurance that the condition is entirely benign and self-resolving.

Although there is no established gold standard treatment confirmed by current evidence, patients with symptomatic GT can be advised on several treatment options prescribed by the clinician on a case-by-case basis. This includes possible prescriptions of antihistamines, anxiolytics, corticosteroids and topical anaesthetics. It is recommended that patients avoid spicy and acidic foods. Research has not shown high levels of evidence for the treatment of symptomatic GT and larger study sizes are needed to come to a reliable recommendation.[20]

Prognosis

The condition may disappear over time, but it is impossible to predict if or when this may happen.[9]

Epidemiology

Geographic tongue is a common condition, affecting 2-3% of the adult general population,[1] although other sources report a prevalence of up to 14%.[12] It is one of the most common tongue disorders that occurs in children.[21] The condition often starts in childhood, sometimes at an early age, but others report that the highest incidence occurs in the over 40 age group.[21] Females are sometimes reported to be more commonly affected than males,[1] in a 2:1 ratio,[4] although others report that the gender distribution is equal.[9]

Psoriasis

A recent study has proven the link between geographic tongue (GT) and psoriasis - the presence of geographic tongue can be a predictor of psoriasis. Clinical manifestation of GT and psoriasis can be histologically similar, however a genetic link between the two has been pathogenically identified. Patients with generalised pustular psoriasis and GT both exhibit the c.115 +6T >C mutation in the IL36RN gene. Patients who have GT have been shown to experience a greater severity of psoriasis and have a less positive response to treatment.[22]

Manifestations in COVID-19 infection

Many articles including case reports, case-series and cross-sectional studies have been done since the 2020 outbreak of COVID-19, causing a global pandemic. These studies have shown that approximately 20% of people with COVID-19 can present with mucosal manifestations in their oral cavities, including geographic tongue. Geographic tongue may appear alongside the onset of the regular symptoms of COVID-19.

Interleukin-6 (IL-6) is known to be an important biomarker in people with COVID-19 in relation to a cytokine storm where too many inflammatory cells which have a detrimental effect on organ systems throughout the body. Geographic tongue is associated with elevated levels of IL-6, which possibly helps explain the presentation in confirmed COVID-19 cases. This evidence is minimal and requires more studies and research to confirm these claims.[23]

Notes

  1. ^ Also known as benign migratory glossitis,[1] erythema migrans,[1] erythema migrans lingualis,[2] glossitis areata exfoliativa,[3] glossitis areata migrans, lingua geographica, psoriasiform mucositis, stomatitis areata migrans, wandering rash of the tongue,[4] and transitory benign plaques of the tongue.[5][6]

References

  1. ^
    ISBN 9780199204830. {{cite book}}: |last= has generic name (help
    )
  2. ^
    ISBN 978-0323112116
    . Retrieved November 12, 2012.
  3. ^ "Geographic Glossitis entry on Medical Subject Headings (MeSH)". National Library of Medicine. Retrieved 19 July 2013.
  4. ^
    ISBN 978-0721690032
    .
  5. ISBN 978-0-7216-2921-6
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  6. ISBN 978-1-4160-2999-1
    .
  7. ^
    ISBN 0-07-138067-1
    .
  8. ISBN 978-8125004400
    . Retrieved November 12, 2012.
  9. ^
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  10. ^
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  11. ^
    ISBN 978-1-60327-519-4
    .
  12. ^
    PMID 20187599
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  13. ^
    ISBN 978-0443073489
    . Retrieved November 12, 2012.
  14. ISBN 978-1-4051-6911-0
    .
  15. PMID 27587983
    .
  16. ^ Migratory Glossitis (Geographic Tongue) on Maxillofacialcenter.com Archived 2005-11-24 at the Wayback Machine.
  17. S2CID 196504048
    .
  18. S2CID 196504048
    . Retrieved 11 March 2022.
  19. PMID 22048588
    .
  20. S2CID 254080778
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  21. ^
    PMID 16264385
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  22. S2CID 73443546
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  23. S2CID 236516140
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External links

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