Piriform cortex

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Piriform cortex
Piriform cortex from a 14-day-old D2-eGFP (green) mouse stained for enkephalin (red) and DAPI (blue) to show nuclei. Epifluorescence.
Human brainstem anterior (piriform cortex not labeled, but most of it is visible near #7)
Details
Identifiers
Latincortex piriformis
MeSHD066195
NeuroNames165
NeuroLex IDbirnlex_1097
FMA62484
Anatomical terms of neuroanatomy

The piriform cortex, or pyriform cortex, is a region in the

the sense of smell
.

Structure

The piriform cortex is part of the rhinencephalon situated in the cerebrum.

In human anatomy, the piriform cortex has been described as consisting of the cortical amygdala, uncus, and anterior parahippocampal gyrus.[1] More specifically, the human piriform cortex is located between the insula and the temporal lobe, anteriorly and laterally of the amygdala.[2][3]

Function

The function of the piriform cortex relates to

olfaction, which is the perception of smell. This has been particularly shown in humans for the posterior piriform cortex.[2]

The piriform cortex in rodents and some primates has been shown to harbor cells expressing markers of plasticity such as doublecortin and PSA-NCAM which are modulated by the noradrenergic neurotransmitter system.[4][5]

Clinical significance

The piriform cortex contains a critical, functionally defined epileptogenic trigger zone, "Area Tempestas".[6] From this site in piriform cortex chemical and electrically evoked seizures can be triggered. It is the site of action for the proconvulsant action of chemoconvulsants.[7]

Other animals

Sometimes called the olfactory cortex, olfactory lobe or paleopallium, piriform cortical regions are present in the brains of

amphibians, reptiles and mammals
.

The piriform cortex is among three areas that emerge in the

archipallial
hippocampus folding toward the midline and down as the dorsal area begins to form a recognizable cortex.

As mammalian brains developed, volume of the dorsal cortex increased in slightly greater proportion, as compared proportionally with increased overall brain volume, until it enveloped the

paleopallial piriform cortex in humans and Old World monkeys
.

Among

telencephalon
in the most recent primate species while the volume of the olfactory bulb becomes less in proportion.

See also

References

  1. ISBN 978-1-4160-3445-2
    .
  2. ^ a b Howard, J. D., Plailly, J., Grueschow, M., Haynes, J. D., & Gottfried, J. A. (2009). Odor quality coding and categorization in human posterior piriform cortex. Nature neuroscience, 12(7), 932-938. Supplementary material, p.4
  3. ^ Mai, J. K. & Paxinos, G. (2008). Atlas of the human brain, 3rd edition. San Diego:: Academic Press. Coronal Atlas – Plate 8 (anterior view). online: http://www.thehumanbrain.info/head_brain/hn_horizontal_atlas/horizontal.html
  4. PMID 29289719
    .
  5. PMID 28237805
    .
  6. PMID 4058572
    .
  7. PMID 9015822
    .

External links
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