SPHK2
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| Location (UCSC) | Chr 19: 48.62 – 48.63 Mb | Chr 7: 45.36 – 45.37 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Sphingosine kinase 2 is a protein that in humans is encoded by the SPHK2 gene.[5]
This gene encodes one of two
tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.[5][6]
The researchers also found that the expression of sphingosine kinase 2 (SphK2) and the secretion of sphingosine-1-phosphate (S1P) were significantly upregulated in the lungs of CS-exposed mice with COPD-like symptoms.[7]
Inhibitors
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000063176 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000057342 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Sphingosine kinase 2". Retrieved 2011-12-22.
- ^ [provided by RefSeq, Aug 2011].
- PMID 36226596.
Further reading
- Liu H, Sugiura M, Nava VE, Edsall LC, Kono K, Poulton S, Milstien S, Kohama T, Spiegel S (June 2000). "Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform". The Journal of Biological Chemistry. 275 (26): 19513–20. PMID 10751414.
- Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA (March 2002). "Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling". The Journal of Biological Chemistry. 277 (10): 7996–8003. PMID 11777919.
- Shu X, Wu W, Mosteller RD, Broek D (November 2002). "Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases". Molecular and Cellular Biology. 22 (22): 7758–68. PMID 12391145.
- Paugh SW, Payne SG, Barbour SE, Milstien S, Spiegel S (November 2003). "The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2". FEBS Letters. 554 (1–2): 189–93. S2CID 41465940.
- Hait NC, Sarkar S, Le Stunff H, Mikami A, Maceyka M, Milstien S, Spiegel S (August 2005). "Role of sphingosine kinase 2 in cell migration toward epidermal growth factor". The Journal of Biological Chemistry. 280 (33): 29462–9. PMID 15951439.
- Okada T, Ding G, Sonoda H, Kajimoto T, Haga Y, Khosrowbeygi A, Gao S, Miwa N, Jahangeer S, Nakamura S (October 2005). "Involvement of N-terminal-extended form of sphingosine kinase 2 in serum-dependent regulation of cell proliferation and apoptosis". The Journal of Biological Chemistry. 280 (43): 36318–25. PMID 16103110.
- Olivera A, Urtz N, Mizugishi K, Yamashita Y, Gilfillan AM, Furumoto Y, Gu H, Proia RL, Baumruker T, Rivera J (February 2006). "IgE-dependent activation of sphingosine kinases 1 and 2 and secretion of sphingosine 1-phosphate requires Fyn kinase and contributes to mast cell responses". The Journal of Biological Chemistry. 281 (5): 2515–25. PMID 16316995.
- Sun J, Yan G, Ren A, You B, Liao JK (September 2006). "FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1". Circulation Research. 99 (5): 468–76. PMID 16888242.
- Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S (April 2007). "Sphingosine kinase type 2 activation by ERK-mediated phosphorylation". The Journal of Biological Chemistry. 282 (16): 12058–65. PMID 17311928.
- Ding G, Sonoda H, Yu H, Kajimoto T, Goparaju SK, Jahangeer S, Okada T, Nakamura S (September 2007). "Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2". The Journal of Biological Chemistry. 282 (37): 27493–502. PMID 17635916.
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