Protein-histidine tele-kinase
 | This article includes a ExPASy NiceZyme view | | |||||||
| KEGG | KEGG entry | ||||||||
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| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In
enzymology, a protein-histidine tele-kinase (EC 2.7.13.2) is an enzyme that catalyzes the chemical reaction
- ATP + protein L-histidine ADP + protein Nτ-phospho-L-histidine
Thus, the two
substrates of this enzyme are ATP and protein L-histidine, whereas its two products are ADP and protein Ntau-phospho-L-histidine
.
This enzyme belongs to the family of transferases, specifically those transferring a phosphate group to the sidechain of histidine residues in proteins (protein-histidine kinases). The systematic name of this enzyme class is ATP:protein-L-histidine Ntau-phosphotransferase. Other names in common use include ATP:protein-L-histidine N-tele-phosphotransferase, histidine kinase, histidine protein kinase, protein histidine kinase, protein kinase (histidine), and HK3.
References
- Fujitaki JM, Fung G, Oh EY, Smith RA (1981). "Characterization of chemical and enzymatic acid-labile phosphorylation of histone H4 using phosphorus-31 nuclear magnetic resonance". Biochemistry. 20 (12): 3658–64. PMID 7196259.
- Huebner VD, Matthews HR (1985). "Phosphorylation of histidine in proteins by a nuclear extract of Physarum polycephalum plasmodia". J. Biol. Chem. 260 (30): 16106–13. PMID 4066704.
