Sodium- and chloride-dependent glycine transporter 2
| SLC6A5 | |||
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Gene ontology | |||
| Molecular function | |||
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| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
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| Location (UCSC) | Chr 11: 20.6 – 20.66 Mb | Chr 7: 49.56 – 49.61 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Sodium- and chloride-dependent glycine transporter 2, also known as glycine transporter 2 (GlyT2), is a protein that in humans is encoded by the SLC6A5 gene.[5]
The glycine transporter 2 is a membrane protein which recaptures
startle reflex. GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration in the presynaptic neuron. Therefore, chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic vesicles.[5][6]
Inhibitors
See also
- Sodium:neurotransmitter symporter
- Solute carrier family
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000165970 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039728 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ S2CID 82276379.
- ^ "Entrez Gene: SLC6A5 solute carrier family 6 (neurotransmitter transporter, glycine), member 5".
Further reading
- López-Corcuera B, Aragón C, Geerlings A (2002). "Regulation of glycine transporters". Biochem. Soc. Trans. 29 (Pt 6): 742–5. PMID 11709067.
- Gallagher MJ, Burgess LH, Brunden KR (1999). "Characterization of multiple forms of the human glycine transporter type-2". Brain Res. Mol. Brain Res. 70 (1): 101–15. PMID 10381548.
- Evans J, Herdon H, Cairns W, et al. (2000). "Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter". FEBS Lett. 463 (3): 301–6. S2CID 21445629.
- Martínez-Maza R, Poyatos I, López-Corcuera B, et al. (2001). "The role of N-glycosylation in transport to the plasma membrane and sorting of the neuronal glycine transporter GLYT2". J. Biol. Chem. 276 (3): 2168–73. PMID 11036075.
- Geerlings A, Núñez E, Rodenstein L, et al. (2002). "Glycine transporter isoforms show differential subcellular localization in PC12 cells". J. Neurochem. 82 (1): 58–65. S2CID 22855247.
- Baliova M, Betz H, Jursky F (2004). "Calpain-mediated proteolytic cleavage of the neuronal glycine transporter, GlyT2". J. Neurochem. 88 (1): 227–32. S2CID 26788320.
- Jamra RA, Villela AW, Klein K, et al. (2006). "No association between genetic variants at the GLYT2 gene and bipolar affective disorder and schizophrenia". Psychiatr. Genet. 16 (3): 91. PMID 16691125.
- Rees MI, Harvey K, Pearce BR, et al. (2006). "Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease". Nat. Genet. 38 (7): 801–6. PMID 16751771.
- Roux M, Supplisson S (2000). "Neuronal and glial glycine transporters have different stoichiometries". Neuron. 25 (2): 373–83. PMID 10719892.
- Aubrey K, Rossi FM, et al. (2007). "The transporters GlyT2 and VIAAT cooperate to determine the vesicular glycinergic phenotype" (PDF). J. Neurosci. 27 (23): 6273–81. PMID 17554001.
- Rousseau F, Aubrey KR, Supplisson S (2008). "The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons." J. Neurosci. 28 (39): 9755–68. PMID 18815261.
- Eulenburg V, Becker K, Gomeza J, et al. (2006). "Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia". Biochem. Biophys. Res. Commun. 348 (2): 400–5. S2CID 27350533.