Terpene synthase N terminal domain

Terpene_synth
SCOP2		5eau / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In molecular biology, this

and domain of the TPS protein.

Function

Terpenes synthases have a role in producing important molecules in metabolism, these molecules are part of a large group called terpenoids . In particular, the N terminal domain has feature of the copalyl diphosphate synthase (CPS) active site.^[1]

Structure

The N-terminal domain forms an alpha-barrel similar to that of the sesquiterpene cyclase epiaristolochene synthase.^[2]

Conservation

Sequences containing this protein domain belong to the terpene synthase family. It has been suggested that this gene family be designated tps (for terpene synthase). Sequence comparisons reveal similarities between the monoterpene (C₁₀) synthases, sesquiterpene (C₁₅) synthases and the diterpene (C₂₀) synthases. It has been split into six subgroups on the basis of phylogeny, called Tpsa-Tpsf .^[3]

• Tpsa includes
  vetispiridiene synthase.^[4]
• Tpsb includes
  (-)-limonene synthase.^[5]
• Tpsc includes
  kaurene synthase A).^[6]
• Tpsd includes taxadiene synthase,^[7] pinene synthase,^[8] and myrcene synthase.^[9]
• Tpse includes
  ent-kaurene synthase B.^[10]
• Tpsf includes S-linalool synthase.^[11] In the fungus Phaeosphaeria sp. (strain L487) the synthesis of ent-kaurene from geranylgeranyl dophosphate is promoted by a single bifunctional protein.^[12]

See also

Terpene synthase C terminal domain

References

This article incorporates text from the public domain Pfam and InterPro: IPR001906