African histoplasmosis
| African histoplasmosis | |
|---|---|
| Specialty | Infectious diseases  |
African histoplasmosis is a fungal infection caused by Histoplasma capsulatum var. duboisii, or Histoplama duboisii (Hcd).[1]: 316 [2] Disease has been most often reported in Uganda, Nigeria, Zaire (Democratic Republic of the Congo) and Senegal, as Hcd is exclusive to Africa.[3] In human disease it manifests differently than histoplasmosis (caused by Histoplasma capsulatum, or Hcc), most often involving the skin and bones and rarely involving the lungs.[4] Also unlike Hcc, Hcd has been reported to rarely present in those with HIV, likely due to underreporting.[5][6][7] However, this along with the differences in Hcc and Hcd have been disputed.[2]
The favored locations of African histoplasmosis are "osteoarticular, ganglionic and pulmonary".[8][9] Genitourinary skin damage is rare, occurring in only 4-11% patients and typically as a secondary skin invasion in those with disseminated infection.[10][11]
It presents as "localized with isolated skin, bone, or lymph node infections or disseminated with multiple cutaneous
See also
References
Further reading
- Gugnani HC, Muotoe-Okafor F (December 1997). "African histoplasmosis: a review" (PDF). Revista Iberoamericana de Micologia. 14 (4): 155–9. PMID 15538817.