Microsporum audouinii
Microsporum audouinii | |
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Scientific classification | |
Domain: | Eukaryota |
Kingdom: | Fungi |
Division: | Ascomycota |
Class: | Eurotiomycetes |
Order: | Onygenales |
Family: | Arthrodermataceae |
Genus: | Microsporum |
Species: | M. audouinii
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Binomial name | |
Microsporum audouinii Gruby (1843)
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Microsporum audouinii is an anthropophilic fungus in the genus Microsporum.[1] It is a type of
Growth conditions
This fungus is often found in soil that is rich in keratinous material.
Epidemiology
Microsporum audouinii causes the infections Tinea capitis (scalp ringworm) and Tinea corporis.[2] These superficial dermal diseases are generally found in prepubescent children (starting at 6 months) and rarely affect adults.[3] There are a few reasons why children are more susceptible to M. audouinii. Differences in the chemical composition and quantity of the triglycerides in hair sebum secreted are the primary reasons.[6] In instances whereby the triglyceride content in the sebum decreases so does the susceptibility of a person to the fungus.[7] Cases like those are seen in postmenopausal women of whom suffer hormonal changes which can contribute to triglyceride reduction.[7] In addition, increased sweat production as well as the presence of Pityrosporum ovale decreases the ability for M. audouinii to thrive.[8][9] Pityrosporum ovale is an opportunistic lipophilic yeast that is a part of the human cutaneous flora in adults.[9] In most cases of adult onset Tinea capitis due to M. audouinii, there is at least one predisposing factor such as immunocompromise (e.g., diabetes mellitus, systemic lupus, organ transplant and HIV), a local animal reservoir (e.g., infected pet or farm animal) and hormonal changes in postmenopausal women.[7][8]
Tinea capitis is seen in tropical, rural and suburban regions.[10] In the 19th and early 20th centuries, M. audouinii was the primary fungus responsible for Tinea capitis throughout the US and Western Europe.[10][11] With the advent of antimycotic agents, its prevalence has decreased.[10] But in the poorer parts of Africa, especially Central and West Africa, M. audouinii remains the primary dermatophyte responsible for this disease.[10][12]
Pathology
Tinea capitis develops when an inoculum from another individual or animal comes into a 'compromised scalp', which can occur when the stratum corneum of the scalp is exposed.[7] This can be due to trauma of the scalp, tight hair braiding or hair styling with infected tools.[7] In general, fungal spread is facilitated by poverty, poor hygiene and overcrowding.[7]
Once the fungus has entered the stratum corneum it continues to invade the epidermis; it then enters a hair follicle, penetrates the hair shaft and grows down the length of the hair.[3] The hyphae grow distally until they reach the upper limits of the zone of keratinization where the nucleated hair shaft cornifies completely and is converted into hard, anucleated keratin.[13] The terminal end of the growing hyphae forms a ring (Adamson's Fringe).[3] As the hair continues to grow outwards, hyphae are brought to the surface (scalp) and arthroconidia are produced.[7] Eventually due to mechanical forces (the movement of the fungi) and keratinase (a chymotrypsin-like enzyme with optimal activity at an acidic pH), all but 1–2 mm of the diseased hair follicle weakens and falls off.[2][3] The remaining hair has a characteristic dark grey appearance due to the Adamson's Fringe.[3]
Diagnostic tests
There is an array of different tests to differentiate between fungi. Direct microscopy with 10% KOH would show small to medium conidia with ectothrix hair invasion.[11] Performing a wet mount would show 'racquet shaped hyphae' with few macro and microconidia.[11] Histological examination of a diseased hair shows clefts that between the inner root sheath and hair.[14]
Microsporum audouinii fluoresces when examined in ultraviolet light (
Microsporum audouinii can be differentiated from non-sporulating strains of the similar M. canis by culture on autoclaved rice. Under these conditions, M. canis typically yields abundant growth and little to no pigmentation whereas M. audouinii produces no visible growth and abundant brown pigment on the rice grains.[16] PCR fingerprinting is a fairly new diagnostic tool for the rapid identification of these fungi.[1][15]
Treatment
A symptomatic patient will present an unusual amount of itching and
Griseofulvin inhibits fungal cell mitosis via disruption of the mitotic spindle structure and preventing cell division at the metaphase stage.[7] In addition, it inhibits nucleic acid synthesis. Both itraconazole and fluconazole inhibits the synthesis of ergosterol which is an important component of fungal cell membranes. Consequently, fluconazole use leads to changes in the permeability and function of the cell membrane.[7] Squalene epoxidase contributes to the formation of ergosterol. Terbinafine inhibits squalene epoxidase thereby preventing cell membrane formation.[7]
References
- ^ PMID 17005755.
- ^ )
- ^ .
- ^ S2CID 38921416.
- ^ S2CID 5746363.
- PMID 15422183.
- ^ PMID 10975696.
- ^ PMID 22837564.
- ^ PMID 8255067.
- ^ PMID 20487688.
- ^ PMID 14622396.
- S2CID 205448257.
- PMID 21769230.
- PMID 21769230.
- ^ ISBN 978-0-7216-7618-0.
- ^ a b c Ellis, Dr.David. "Microsporum audouinii". The University of Adelaide. Archived from the original on 14 December 2013. Retrieved 18 October 2013.
- ^ PMID 22998181.
- ^ PMID 10367913.
External links
- Index Fungorum Synonyms