Prenylflavonoid

Prenylated flavonoids or prenylflavonoids are a sub-class of

Monoprenyl isoflavone epoxidase is a key enzyme in fungal Botrytis cinerea metabolism of prenylated flavonoids.^[3]

Many prenylflavonoids appear to have anticancer activity in vitro.^[4]

Prenylchalcones, prenylflavones, prenylflavonols and prenylflavanones are classes of prenylflavonoids.

Examples

6-Prenylnaringenin, 6-geranylnaringenin, 8-prenylnaringenin and isoxanthohumol can be found in hops and beer.^[5][6] Of the prenylflavonoids, 8-prenylnaringenin is the most potent phytoestrogen known.

Australone A can be found in Morus australis.^[7]

6,8-Diprenyleriodictyol, dorsmanin C and dorsmanin F can be found in Dorstenia mannii.^[1]

Epimedium wushanense contains a number of flavanoids. 37 compounds were characterized from the underground and aerial parts of the plant. Among them, 28 compounds were prenylflavonoids. The predominant prenylated flavonoid, epimedin C,^[8] ranged from 1.4 to 5.1% in aerial parts and 1.0 to 2.8% in underground parts.^[9]

Artocarpus nobilis contains prenylated flavonoids in its root bark.^[10]

8-Prenylkaempferol can be found in Sophora flavescens.^[11]

Cannflavins are prenylflavonoids found in Cannabis sativa.^[12]

Prenylated isoflavonoids

A number of bio-active chemicals have been reported from

7-O-Methylluteone is a prenylated isoflavone. It can be found in the bark of Erythrina burttii.

Luteone is another prenylated isoflavone found in the pods of Laburnum anagyroides.

Wighteone (6-prenylgenistein), isowighteone (3′-prenylgenistein), and lupiwighteone (8-prenylgenistein) are genistein prenylated derivatives.^[2]

References