Pyrrolobenzodiazepine
This article relies largely or entirely on a single source. (October 2020) |
Pyrrolobenzodiazepines, (PBD) are a class of compound that may have antibiotic or anti-tumor properties.[1]
Some dimeric pyrrolobenzodiazepines are used as the cytotoxic drug payloads in
antibody-drug conjugates, for example in loncastuximab tesirine
.
History
Anthramycin, the first PBD monomer, was first synthesized in the 1960s.[2]