Metaclazepam

Source: Wikipedia, the free encyclopedia.
Metaclazepam
Clinical data
Trade namesTalis
ATC code
  • none
Identifiers
  • 7-bromo-5-(2-chlorophenyl)-2-(methoxymethyl)-1-methyl-2,3-dihydro-1,4-benzodiazepine
JSmol)
  • ClC1=CC=CC=C1C2=NCC(COC)N(C)C3=C2C=C(Br)C=C3
  • InChI=1S/C18H18BrClN2O/c1-22-13(11-23-2)10-21-18(14-5-3-4-6-16(14)20)15-9-12(19)7-8-17(15)22/h3-9,13H,10-11H2,1-2H3 checkY
  • Key:WABYCCJHARSRBH-UHFFFAOYSA-N checkY
  (verify)

Metaclazepam[1] (marketed under the brand name Talis) is a drug which is a benzodiazepine derivative.[2][3] It is a relatively selective anxiolytic with less sedative or muscle relaxant properties than other benzodiazepines such as diazepam or bromazepam.[4] It has an active metabolite N-desmethylmetaclazepam, which is the main metabolite of metaclazepam.[5] There is no significant difference in metabolism between younger and older individuals.[6]

Metaclazepam is slightly more effective as an anxiolytic than

Fatigue is a common side effect from metaclazepam at high doses.[11] Small amounts of metaclazepam as well as its metabolites enter into human breast milk.[12]

See also

References

  1. ^ US 4098786 
  2. S2CID 12290664
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