Doxefazepam

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Doxefazepam
Clinical data
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
MetabolismHepatic
Elimination half-life3-4 hours[1]
ExcretionRenal
Identifiers
  • 9-chloro-6-(2-fluorophenyl)-4-hydroxy-2-(2-hydroxyethyl)-2,5-diazabicyclo[5.4.0]undeca-5,8,10,12-tetraen-3-one
JSmol)
  • FC1=CC=CC=C1C2=NC(C(N(CCO)C3=C2C=C(C=C3)Cl)=O)O
  • InChI=1S/C17H14ClFN2O3/c18-10-5-6-14-12(9-10)15(11-3-1-2-4-13(11)19)20-16(23)17(24)21(14)7-8-22/h1-6,9,16,22-23H,7-8H2 checkY
  • Key:VOJLELRQLPENHL-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)

Doxefazepam (marketed under brand name Doxans) is a

skeletal muscle relaxant properties. It is used therapeutically as a hypnotic.[2] According to Babbini and colleagues in 1975, this derivative of flurazepam was between 2 and 4 times more potent than the latter while at the same time being half as toxic in laboratory animals.[3]

It was patented in 1972 and came into medical use in 1984.[4]

Side effects

Section 5.5 of the article Doxefazepam in volume 66 of the World Health Organization's (WHO) and International Agency for Research on Cancer's (IARC) IARC Monographs On The Evaluation Of Carcinogenic Risks To Humans, an article describing the carcinogenic/toxic effects of doxefazepam on humans and experimental animals, states that there is "inadequate evidence in humans for the carcinogenicity of doxefazepam" and limited evidence in experimental for the carcinogenicity of doxefazepam," and concluded that the overall evaluation of the substance's carcinogenicity to humans is "not classifiable."[5]

See also

References

  1. ^ "Doxefazepam". IPCS INTOX. Archived from the original on 24 July 2008.
  2. PMID 6483162
    .
  3. PMID 241364
    .
  4. ISBN 9783527607495
    .
  5. PMID 9097119
    . Retrieved 10 July 2014.

External links
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