Tifluadom

Source: Wikipedia, the free encyclopedia.
Tifluadom
Clinical data
Routes of
administration		unknown
ATC code
  • none
Identifiers
  • N-[[5-(2-Fluorophenyl)-1-methyl-2,3-dihydro-1,4-benzodiazepin-2-yl]methyl]thiophene-3-carboxamide
JSmol)
  • O=C(NCC1N(c3ccccc3C(=N/C1)\c2ccccc2F)C)c4ccsc4
  • InChI=1S/C22H20FN3OS/c1-26-16(13-25-22(27)15-10-11-28-14-15)12-24-21(17-6-2-4-8-19(17)23)18-7-3-5-9-20(18)26/h2-11,14,16H,12-13H2,1H3,(H,25,27) checkY
  • Key:NPGABYHTDVGGJK-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Tifluadom is a

κ-opioid receptor.[2] It has potent analgesic[3] and diuretic[4] effects in animals, and also has sedative effects and stimulates appetite.[5][6]

While tifluadom has several effects which might have potential uses in medicine, such as analgesia and appetite stimulation, κ-opioid agonists tend to produce undesirable effects in humans such as

scientific research. Dysphoric effects are similar to those seen when using other κ-opioid receptor agonists like pentazocine and salvinorin A
, and can be considered the opposite of morphine-induced euphoria. As such, kappa agonists are believed to have very limited abuse potential.

See also

  • Lufuradom
  • GYKI-52895
    , a benzodiazepine which is a dopamine reuptake inhibitor without GABAergic function
  • GYKI-52,466
    , a benzodiazepine which is an AMPAkine and glutamate antagonist without GABAergic function

References

  1. ^ US 4325957, Zeugner H, Roemer D, Liepmann H, Milkowski W, "2-Acylaminomethyl-1,4-benzodiazepine derivatives and their salts and pharmaceutical compositions thereof", issued 20 April 1982, assigned to Abbott Products GmbH 
  2. PMID 6292610
    .
  3. PMID 3773641
    .
  4. S2CID 31380360
    .
  5. S2CID 13046110
    .
  6. PMID 3612543
    .
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