Imidazenil

Source: Wikipedia, the free encyclopedia.
Imidazenil
Clinical data
ATC code
  • none
Identifiers
  • 6-(2-Bromophenyl)-8-fluoro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxamide
JSmol)
  • Brc4ccccc4C/2=N/Cc1c(ncn1c3c\2cc(F)cc3)C(=O)N
  • InChI=1S/C18H12BrFN4O/c19-13-4-2-1-3-11(13)16-12-7-10(20)5-6-14(12)24-9-23-17(18(21)25)15(24)8-22-16/h1-7,9H,8H2,(H2,21,25) checkY
  • Key:OCJHYHKWUWSHEN-UHFFFAOYSA-N checkY
  (verify)

Imidazenil[1] is an experimental anxiolytic drug which is derived from the benzodiazepine family, and is most closely related to other imidazobenzodiazepines such as midazolam, flumazenil, and bretazenil.

Imidazenil is a highly potent

amnestic[3] effects. In fact, imidazenil blocks the sedative effects of diazepam, yet without lowering the convulsion threshold,[4] and so potentially could be a more flexible antidote than the antagonist flumazenil which is commonly used to treat benzodiazepine overdose
at present.

Imidazenil has not yet been developed commercially for use in humans, however it has been suggested as a safe and effective treatment for anxiety,[5] a potent yet non-sedating anticonvulsant which might be particularly useful in the treatment of poisoning with organophosphate nerve agents,[6][7] and as a novel treatment for schizophrenia.[8]

In rats, imidazenil has been demonstrated to have low tolerance or dependence liability, unlike other benzodiazepine receptor agonist ligands, such as diazepam, bretazenil.[9]

See also

References

  1. ^ US 5317018 
  2. PMID 7791102
    .
  3. S2CID 24584434
    .
  4. S2CID 44619421
    .
  5. PMID 12871032
    .
  6. S2CID 2066413
    .
  7. S2CID 41221807
    .
  8. S2CID 25147595
    .
  9. PMID 7932179.{{cite journal}}: CS1 maint: multiple names: authors list (link
    )
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