Flutoprazepam

Source: Wikipedia, the free encyclopedia.
Flutoprazepam
Clinical data
Trade namesRestas
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral, Intravenous
ATC code
  • none
Legal status
Legal status
Pharmacokinetic data
Bioavailability80-90%
MetabolismHepatic
Elimination half-life60-90 hours
ExcretionRenal
Identifiers
  • 7-chloro-1-(cyclopropylmethyl)-5-(2-fluorophenyl)-3H-1,4-benzodiazepin-2-one
JSmol)
  • FC1=CC=CC=C1C2=NCC(N(CC3CC3)C4=C2C=C(C=C4)Cl)=O
  • InChI=1S/C19H16ClFN2O/c20-13-7-8-17-15(9-13)19(14-3-1-2-4-16(14)21)22-10-18(24)23(17)11-12-5-6-12/h1-4,7-9,12H,5-6,10-11H2 checkY
  • Key:OFVXPDXXVSGEPX-UHFFFAOYSA-N checkY
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Flutoprazepam (Restas) is a drug which is a

desalkylflurazepam, also known as norflurazepam, which is also a principal metabolite of flurazepam (trade name Dalmadorm/Dalmane).[5][6]

Flutoprazepam is typically used for the treatment of severe

stomach ulcers.[7]

Flutoprazepam does not fall under the international Convention on Psychotropic Substances of 1971, and is currently unscheduled in the United States.[8]

  • In Singapore, flutoprazepam is a Class C-Schedule II drug under the Misuse of Drugs Act.
  • In Thailand, flutoprazepam is a Schedule III psychotropic substance.
  • In Hong Kong, flutoprazepam is regulated under Schedule 1 of Hong Kong's Chapter 134 Dangerous Drugs Ordinance. Flutoprazepam can only be used legally by health professionals and for university research purposes. The substance can be given by pharmacists under a prescription. Anyone who supplies the substance without prescription can be fined $10000 (HKD). The penalty for trafficking or manufacturing the substance is a $5,000,000 (HKD) fine and life imprisonment. Possession of the substance for consumption without license from the Department of Health is illegal with a $1,000,000 (HKD) fine and/or 7 years of jail time.[9]

See also

References

  1. ^ US patent 3632574, Hisao Yamamoto et al, "PROCESS FOR PRODUCING BENZODIAZEPINE DERIVATIVES", published 1968-29-04, issued 1972-04-01 
  2. PMID 7203280
    .
  3. PMID 6890927
    .
  4. S2CID 20710732
    .
  5. PMID 15869852
    .
  6. S2CID 20710732
    .
  7. PMID 7052359
    .
  8. ^ "Green List—List of psychotropic substances under international control" (PDF) (26th ed.). International Narcotics Control Board. August 2016. Archived from the original (PDF) on 2017-04-21. Retrieved 2017-07-30.
  9. ^ "Bilingual Laws Information System" (English). The Government of the Hong Kong Special Administrative Region of the People's Republic of China.
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