Bentazepam

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Bentazepam
Clinical data
Trade namesTiadipona (ES)
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral (tablets)
ATC code
Legal status
Legal status
  • US: Unscheduled
Pharmacokinetic data
MetabolismHepatic
Elimination half-life2–4 hours
ExcretionRenal
Identifiers
  • 5-phenyl-3,4,6,7,8,9-hexahydro-[1]benzothiolo[2,3-e][1,4]diazepin-2-one
JSmol)
  • O=C1CN=C(C2=CC=CC=C2)C3=C(N1)SC4=C3CCCC4
  • InChI=1S/C17H16N2OS/c20-14-10-18-16(11-6-2-1-3-7-11)15-12-8-4-5-9-13(12)21-17(15)19-14/h1-3,6-7H,4-5,8-10H2,(H,19,20) checkY
  • Key:AIZFEOPQVZBNGH-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Bentazepam[1] (also known as Thiadipone, Tiadipona) is a thienodiazepine which is a benzodiazepine analog.[2]

It possesses

skeletal muscle relaxant
properties. Peak plasma rates are achieved in around 2,5 hours after oral administration.[3] The elimination half-life is between approximately 2–4 hours.[2][4] Bentazepam is effective as an anxiolytic.

A severe

dyspepsia, constipation, nausea[6] and drug-induced lymphocytic colitis has been associated with bentazepam.[7][8] Severe liver damage and hepatitis has also been associated with bentazepam.[9][10][11] Whilst liver failure from bentazepam is considered to be rare, liver function monitoring has been recommended for all patients taking bentazepam.[12]

See also

References

  1. ^ DE 2005276 
  2. ^
    PMID 2877954
    .
  3. PMID 3429066
    .
  4. PMID 1800395
    .
  5. PMID 2565591
    .
  6. PMID 1983365
    .
  7. S2CID 1983209
    .
  8. PMID 9451703
    .
  9. S2CID 9067701
    .
  10. doi:10.1157/13047309. Archived from the original
    on 2018-09-16. Retrieved 2009-09-18.
  11. S2CID 33991843
    .
  12. PMID 10961721
    .
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