Flutazolam

Source: Wikipedia, the free encyclopedia.
Not to be confused with Fluetizolam.
Flutazolam
Clinical data
Trade namesCoreminal (JP)
Other names13-chloro- 2-(2-fluorophenyl)- 9-(2-hydroxyethyl)- 3-oxa- 6,9-diazatricyclo[8.4.0.02,6] tetradeca-1(10),11,13- trien- 8-one
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
Legal status
Legal status
  • US: Unscheduled
  • In general: unscheduled, Rx-only in Japan
Pharmacokinetic data
MetabolismHepatic
Elimination half-life3.5 hours (parent compound); 47-100 hours (major metabolite)
Identifiers
  • 10-chloro-11b-(2-fluorophenyl)-7-(2-hydroxyethyl)-3,5-dihydro-2H-[1,3]oxazolo[3,2-d][1,4]benzodiazepin-6-one
JSmol)
  • Fc1ccccc1C42OCCN2CC(=O)N(c3c4cc(Cl)cc3)CCO
  • InChI=1S/C19H18ClFN2O3/c20-13-5-6-17-15(11-13)19(14-3-1-2-4-16(14)21)22(8-10-26-19)12-18(25)23(17)7-9-24/h1-6,11,24H,7-10,12H2 checkY
  • Key:WMFSSTNVXWNLKI-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Flutazolam

desalkylflurazepam, also known as norflurazepam, which is also a principal metabolite of flurazepam (trade name Dalmane).[3] While flutazolam has a very short half-life of only 3.5 hours, n-desalkylflurazepam has a long half-life of between 47–100 hours.[4]

Flutazolam is closely related in structure to another benzodiazepine, haloxazolam.[5][6]

See also

References

  1. ^ DE 1952486 
  2. ^ Mitsushima T, Ueki S. Psychopharmacological effects of flutazolam (MS-4101). Nippon Yakurigaku Zasshi. 1978 Nov;74(8):959-79. (Japanese).
  3. PMID 15869852
    .
  4. ^ "Dalmane Prescribing Information" (PDF). Prescribing Information for Dalmane. FDA. Retrieved 3 April 2022.
  5. PMID 2870816
    .
  6. PMID 2894449
    .
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