Female infertility: Difference between revisions
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====Tobacco smoking==== |
====Tobacco smoking==== |
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{{See also|Women and smoking#Unique gender differences and health effects for Females}} |
{{See also|Women and smoking#Unique gender differences and health effects for Females}} |
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[[Tobacco smoking]] is harmful to the ovaries, and the degree of damage is dependent upon the amount and length of time a woman smokes or is exposed to a smoke-filled environment. Nicotine and other harmful chemicals in cigarettes interfere with the body’s ability to create [[estrogen]], a hormone that regulates [[folliculogenesis]] and [[ovulation]]. Also, cigarette smoking interferes with folliculogenesis, embryo transport, endometrial receptivity, endometrial angiogenesis, uterine blood flow and the uterine myometrium.<ref>{{cite journal|vauthors=Dechanet C, Anahory T, Mathieu Daude JC, Quantin X, Reyftmann L, Hamamah S, Hedon B, Dechaud H | title = Effects of cigarette smoking on reproduction| journal = Hum. Reprod. Update| volume = 17| issue = 1| pages = 76–95| year = 2011| pmid = 20685716| doi = 10.1093/humupd/dmq033| url = }}</ref> Some damage is irreversible, but stopping smoking can prevent further damage.<ref name=asrm-risks>[http://www.protectyourfertility.com/femalerisks.html FERTILITY FACT > Female Risks] {{webarchive |url=https://web.archive.org/web/20070922184324/http://www.protectyourfertility.com/femalerisks.html |date=September 22, 2007 }} By the American Society for Reproductive Medicine (ASRM). Retrieved on Jan 4, 2009</ref><ref name="bare_url">http://dl.dropbox.com/u/8256710/ASRM%20Protect%20Your%20Fertility%20newsletter.pdf</ref> Smokers are 60% more likely to be infertile than non-smokers.<ref name=dh2009/> Smoking reduces the chances of IVF producing a live birth by 34% and increases the risk of an IVF pregnancy miscarrying by 30%.<ref name=dh2009>[http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_101070 Regulated fertility services: a commissioning aid - June 2009], from the Department of Health UK</ref> Also, female smokers have an earlier onset of [[menopause]] by approximately 1–4 years.<ref name = "smoking and infertility">{{cite journal |author=Practice Committee of American Society for Reproductive Medicine |title=Smoking and Infertility |journal=Fertil Steril |volume=90 |issue=5 Suppl |pages=S254–9 |year=2008 |pmid=19007641 |url=http://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)03535-8 |doi=10.1016/j.fertnstert.2008.08.035}}</ref> |
[[Tobacco smoking]] is harmful to the ovaries, and the degree of damage is dependent upon the amount and length of time a woman smokes or is exposed to a smoke-filled environment. Nicotine and other harmful chemicals in cigarettes interfere with the body’s ability to create [[estrogen]], a hormone that regulates [[folliculogenesis]] and [[ovulation]]. Also, cigarette smoking interferes with folliculogenesis, embryo transport, endometrial receptivity, endometrial angiogenesis, uterine blood flow and the uterine myometrium.<ref>{{cite journal|vauthors=Dechanet C, Anahory T, Mathieu Daude JC, Quantin X, Reyftmann L, Hamamah S, Hedon B, Dechaud H | title = Effects of cigarette smoking on reproduction| journal = Hum. Reprod. Update| volume = 17| issue = 1| pages = 76–95| year = 2011| pmid = 20685716| doi = 10.1093/humupd/dmq033| url = }}</ref> Some damage is irreversible, but stopping smoking can prevent further damage.<ref name=asrm-risks>[http://www.protectyourfertility.com/femalerisks.html FERTILITY FACT > Female Risks] {{webarchive |url=https://web.archive.org/web/20070922184324/http://www.protectyourfertility.com/femalerisks.html |date=September 22, 2007 }} By the American Society for Reproductive Medicine (ASRM). Retrieved on Jan 4, 2009</ref><ref name="bare_url">http://dl.dropbox.com/u/8256710/ASRM%20Protect%20Your%20Fertility%20newsletter.pdf{{dead link|date=January 2018 |bot=InternetArchiveBot |fix-attempted=yes }}</ref> Smokers are 60% more likely to be infertile than non-smokers.<ref name=dh2009/> Smoking reduces the chances of IVF producing a live birth by 34% and increases the risk of an IVF pregnancy miscarrying by 30%.<ref name=dh2009>[http://www.dh.gov.uk/en/Publicationsandstatistics/Publications/PublicationsPolicyAndGuidance/DH_101070 Regulated fertility services: a commissioning aid - June 2009], from the Department of Health UK</ref> Also, female smokers have an earlier onset of [[menopause]] by approximately 1–4 years.<ref name = "smoking and infertility">{{cite journal |author=Practice Committee of American Society for Reproductive Medicine |title=Smoking and Infertility |journal=Fertil Steril |volume=90 |issue=5 Suppl |pages=S254–9 |year=2008 |pmid=19007641 |url=http://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)03535-8 |doi=10.1016/j.fertnstert.2008.08.035}}</ref> |
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====Sexually transmitted infections==== |
====Sexually transmitted infections==== |
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====Hypothalamic-pituitary factors==== |
====Hypothalamic-pituitary factors==== |
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*[[Hypothalamic dysfunction]] |
*[[Hypothalamic dysfunction]] |
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*[[Hyperprolactinemia]]<ref>[http://www.getting-pregnant-tips.com/female-infertility.html Female Infertility]</ref> |
*[[Hyperprolactinemia]]<ref>[http://www.getting-pregnant-tips.com/female-infertility.html Female Infertility] {{webarchive|url=https://web.archive.org/web/20100218012801/http://www.getting-pregnant-tips.com/female-infertility.html |date=2010-02-18 }}</ref> |
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====Ovarian factors==== |
====Ovarian factors==== |
Revision as of 16:47, 15 January 2018
Female infertility | |
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Specialty | Gynaecology |
Female infertility refers to infertility in female humans. It affects an estimated 48 million women[1] with the highest prevalence of infertility affecting people in South Asia, Sub-Saharan Africa, North Africa/Middle East, and Central/Eastern Europe and Central Asia.[1] Infertility is caused by many sources, including nutrition, diseases, and other malformations of the uterus. Infertility affects women from around the world, and the cultural and social stigma surrounding it varies.
Definition
There is no unanimous definition of female infertility, because the definition depends on social and physical characteristics which may vary by culture and situation.
Prevalence
Female infertility varies widely by geographic location around the world. In 2010, there was an estimated 48.5 million infertile couples worldwide, and from 1990 to 2010 there was little change in levels of infertility in most of the world.[1] In 2010, the countries with the lowest rates of female infertility included the South American countries of Peru, Ecuador and Bolivia, as well as in Poland, Kenya, and Republic of Korea.[1] The highest rate regions included Eastern Europe, North Africa, the Middle East, Oceania, and Sub-Saharan Africa.[1] The prevalence of primary infertility has increased since 1990, but secondary infertility has decreased overall. Rates decreased (although not prevalence) of female infertility in high-income, Central/Eastern Europe, and Central Asia regions.[1]
Africa
Sub-Saharan Africa has had decreasing levels of primary infertility from 1990 to 2010. Within the Sub-Saharan region, rates were lowest in Kenya, Zimbabwe, and Rwanda, while the highest rates were in Guinea, Mozambique, Angola, Gabon, and Cameroon along with Northern Africa near the Middle East.[1] According to a 2004 DHS report, rates in Africa were highest in Middle and Sub-Saharan Africa, with East Africa’s rates close behind.[6]
Asia
In Asia, the highest rates of combined secondary and primary infertility was in the South Central region, and then in the Southeast region, with the lowest rates in the Western areas.[6]
Latin America and Caribbean
The prevalence of female infertility in the Latin America/Caribbean region is typically lower than the global prevalence. However, the greatest rates occurred in Jamaica, Suriname, Haiti, and Trinidad and Tobago. Central and Western Latin America has some of the lowest rates of prevalence.[1] The highest regions in Latin America and the Caribbean was in the Caribbean Islands and in less developed countries.[6]
Causes and factors
Causes or factors of female infertility can basically be classified regarding whether they are
Although factors of female infertility can be classified as either acquired or genetic, female infertility is usually more or less a combination of
Acquired
According to the American Society for Reproductive Medicine (ASRM), Age, Smoking, Sexually Transmitted Infections, and Being Overweight or Underweight can all affect fertility.[7]
In broad sense, acquired factors practically include any factor that is not based on a
Age
A woman's fertility is affected by her age. The average age of a girl's first period (
Tobacco smoking
Tobacco smoking is harmful to the ovaries, and the degree of damage is dependent upon the amount and length of time a woman smokes or is exposed to a smoke-filled environment. Nicotine and other harmful chemicals in cigarettes interfere with the body’s ability to create estrogen, a hormone that regulates folliculogenesis and ovulation. Also, cigarette smoking interferes with folliculogenesis, embryo transport, endometrial receptivity, endometrial angiogenesis, uterine blood flow and the uterine myometrium.[13] Some damage is irreversible, but stopping smoking can prevent further damage.[14][15] Smokers are 60% more likely to be infertile than non-smokers.[16] Smoking reduces the chances of IVF producing a live birth by 34% and increases the risk of an IVF pregnancy miscarrying by 30%.[16] Also, female smokers have an earlier onset of menopause by approximately 1–4 years.[17]
Sexually transmitted infections
Sexually transmitted infections are a leading cause of infertility. They often display few, if any visible symptoms, with the risk of failing to seek proper treatment in time to prevent decreased fertility.[14]
Body weight and eating disorders
Twelve percent of all infertility cases are a result of a woman either being underweight or overweight. Fat cells produce estrogen,[18] in addition to the primary sex organs. Too much body fat causes production of too much estrogen and the body begins to react as if it is on birth control, limiting the odds of getting pregnant.[14] Too little body fat causes insufficient production of estrogen and disruption of the menstrual cycle.[14] Both under and overweight women have irregular cycles in which ovulation does not occur or is inadequate.[14] Proper nutrition in early life is also a major factor for later fertility.[19]
A study in the US indicated that approximately 20% of infertile women had a past or current eating disorder, which is five times higher than the general lifetime prevalence rate.[20]
A review from 2010 concluded that overweight and obese subfertile women have a reduced probability of successful fertility treatment and their pregnancies are associated with more complications and higher costs.[21] In hypothetical groups of 1000 women undergoing fertility care, the study counted approximately 800 live births for normal weight and 690 live births for overweight and obese anovulatory women. For ovulatory women, the study counted approximately 700 live births for normal weight, 550 live births for overweight and 530 live births for obese women. The increase in cost per live birth in anovulatory overweight and obese women were, respectively, 54 and 100% higher than their normal weight counterparts, for ovulatory women they were 44 and 70% higher, respectively.[22]
Chemotherapy
Chemotherapy poses a high risk of infertility. Chemotherapies with high risk of infertility include procarbazine and other alkylating drugs such as cyclophosphamide, ifosfamide, busulfan, melphalan, chlorambucil and chlormethine.[23] Drugs with medium risk include doxorubicin and platinum analogs such as cisplatin and carboplatin.[23] On the other hand, therapies with low risk of gonadotoxicity include plant derivatives such as vincristine and vinblastine, antibiotics such as bleomycin and dactinomycin and antimetabolites such as methotrexate, mercaptopurine and 5-fluorouracil.[23]
Female infertility by chemotherapy appears to be secondary to
Women may choose between several methods of fertility preservation prior to chemotherapy, including cryopreservation of ovarian tissue, oocytes or embryos.[26]
Immune infertility
Antisperm antibodies (ASA) have been considered as infertility cause in around 10–30% of infertile couples.[27] ASA production are directed against surface antigens on sperm, which can interfere with sperm motility and transport through the female reproductive tract, inhibiting capacitation and acrosome reaction, impaired fertilization, influence on the implantation process, and impaired growth and development of the embryo. Factors contributing to the formation of antisperm antibodies in women are disturbance of normal immunoregulatory mechanisms, infection, violation of the integrity of the mucous membranes, accidental rape and unprotected oral or anal sex.[27][28]
Other acquired factors
- Adhesions secondary to surgery in the peritoneal cavity is the leading cause of acquired infertility.[29] A meta-analysis in 2012 came to the conclusion that there is only little evidence for the surgical principle that using less invasive techniques, introducing less foreign bodies or causing less ischemia reduces the extent and severity of adhesions.[29]
- amenorrea, infertility or early menopause; and pregnancy complications, such as intrauterine growth restriction (IUGR), small for gestational age (SGA) babies, recurrent abortions, preterm deliveries or low birth weight (LBW) babies. Nevertheless, gluten-free diet reduces the risk. Some authors suggest that physicians should investigate the presence of undiagnosed coeliac disease in women with unexplained infertility, recurrent miscarriage or IUGR.[31][32]
- Significant liver or kidney disease
- Thrombophilia[33][34]
- marijuana causes disturbances in the endocannabinoid system, potentially causing infertility[35]
- Radiation, such as in radiation therapy. The radiation dose to the ovaries that generally causes permanent female infertility is 20.3 Gy at birth, 18.4 Gy at 10 years, 16.5 Gy at 20 years and 14.3 Gy at 30 years.[36] After total body irradiation, recovery of gonadal function occurs in 10−14% of cases, and the number of pregnancies observed after hematopoietic stem cell transplantation involving such as procedure is lower than 2%.[37][38]
Genetic factors
There are many
Some of these gene or chromosome abnormalities cause
Gene | Encoded protein | Effect of deficiency | |
---|---|---|---|
BMP15 |
Bone morphogenetic protein 15 | Hypergonadotrophic ovarian failure (POF4) | |
BMPR1B | Bone morphogenetic protein receptor 1B |
Ovarian dysfunction, hypergonadotrophic hypogonadism and acromesomelic chondrodysplasia | |
CBX2; M33 | Chromobox protein homolog 2 ; Drosophila polycomb class |
Autosomal 46,XY, male-to-female sex reversal (phenotypically perfect females) | |
CHD7 | Chromodomain-helicase-DNA-binding protein 7 | CHARGE syndrome and Kallmann syndrome (KAL5) | |
DIAPH2 | Diaphanous homolog 2 | Hypergonadotrophic, premature ovarian failure (POF2A) | |
FGF8 |
Fibroblast growth factor 8 | Normosmic hypogonadotrophic hypogonadism and Kallmann syndrome (KAL6) | |
FGFR1 |
Fibroblast growth factor receptor 1 | Kallmann syndrome (KAL2) | |
HFM1 | Primary ovarian failure[42]
| ||
FSHR |
FSH receptor |
Hypergonadotrophic hypogonadism and ovarian hyperstimulation syndrome | |
FSHB | Follitropin subunit beta |
Deficiency of follicle-stimulating hormone, primary amenorrhoea and infertility | |
FOXL2 | Forkhead box L2 |
Isolated premature ovarian failure (POF3) associated with BPES type I; FOXL2
402C --> G mutations associated with human granulosa cell tumours | |
FMR1 | Fragile X mental retardation |
Premature ovarian failure (POF1) associated with premutations | |
GNRH1 |
Gonadotropin releasing hormone |
Normosmic hypogonadotrophic hypogonadism | |
GNRHR | GnRH receptor |
Hypogonadotrophic hypogonadism | |
KAL1 |
Kallmann syndrome | Hypogonadotrophic hypogonadism and insomnia, X-linked Kallmann syndrome (KAL1) | |
GPR54 |
KISS1 receptor | Hypogonadotrophic hypogonadism | |
LHB | Luteinizing hormone beta polypeptide | Hypogonadism and pseudohermaphroditism | |
LHCGR |
LH/choriogonadotrophin receptor |
Hypergonadotrophic hypogonadism (luteinizing hormone resistance) | |
DAX1 | Dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1 |
X-linked congenital adrenal hypoplasia with hypogonadotrophic hypogonadism; dosage-sensitive male-to-female sex reversal | |
NR5A1; SF1 |
Steroidogenic factor 1 | 46,XY male-to-female sex reversal and streak gonads and congenital lipoid adrenal hyperplasia; 46,XX gonadal dysgenesis and 46,XX primary ovarian insufficiency | |
POF1B | Premature ovarian failure 1B | Hypergonadotrophic, primary amenorrhea (POF2B) | |
PROK2 | Prokineticin | Normosmic hypogonadotrophic hypogonadism and Kallmann syndrome (KAL4) | |
PROKR2 |
Prokineticin receptor 2 | Kallmann syndrome (KAL3) | |
RSPO1 |
R-spondin family, member 1 | 46,XX, female-to-male sex reversal (individuals contain testes) | |
SRY |
Sex-determining region Y |
Mutations lead to 46,XY females; translocations lead to 46,XX males | |
SOX9 | SRY-related HMB-box gene 9 | Autosomal 46,XY male-to-female sex reversal (campomelic dysplasia) | |
STAG3 |
Stromal antigen 3 |
Premature ovarian failure[43]
| |
TAC3 | Tachykinin 3 | Normosmic hypogonadotrophic hypogonadism | |
TACR3 |
Tachykinin receptor 3 | Normosmic hypogonadotrophic hypogonadism | |
ZP1 | zona pellucida glycoprotein 1 |
Dysfunctional zona pellucida formation[44] |
By location
Hypothalamic-pituitary factors
- Hypothalamic dysfunction
- Hyperprolactinemia[45]
Ovarian factors
- Chemotherapy (as detailed previously) with certain agents have a high risk of toxicity on the ovaries.
- Many genetic defects (as also detailed previously) also disturb ovarian function.
- Polycystic ovary syndrome (also see infertility in polycystic ovary syndrome)
- Anovulation. Female infertility caused by anovulation is called "anovulatory infertility", as opposed to "ovulatory infertility" in which ovulation is present.[46]
- Diminished ovarian reserve, also see Poor Ovarian Reserve
- Premature menopause
- Menopause
- Luteal dysfunction[47]
- Gonadal dysgenesis (Turner syndrome)
- Ovarian cancer
Tubal (ectopic)/peritoneal factors
- Endometriosis (also see endometriosis and infertility)
- Pelvic adhesions
- chlamydia)[48]
- Tubal occlusion[49]
- Tubal dysfunction
- Previous ectopic pregnancy. A randomized study in 2013 came to the result that the rates of intrauterine pregnancy 2 years after treatment of ectopic pregnancy are approximately 64% with radical surgery, 67% with medication, and 70% with conservative surgery.[50] In comparison, the cumulative pregnancy rate of women under 40 years of age in the general population over 2 years is over 90%.[2]
Uterine factors
- Uterine malformations[51]
- Uterine fibroids
- Asherman's Syndrome[52]
- Implantation failure without any known primary cause. It results in negative pregnancy test despite having performed e.g. embryo transfer.
Previously, a bicornuate uterus was thought to be associated with infertility,[53] but recent studies have not confirmed such an association.[54]
Cervical factors
- Cervical stenosis[55]
- Antisperm antibodies[28]
- Non-receptive cervical mucus[56]
Vaginal factors
- Vaginismus
- Vaginal obstruction
Diagnosis
Diagnosis of infertility begins with a
- Lab tests
- hormone testing, to measure levels of female hormones at certain times during a menstrual cycle
- day 2 or 3 measure of FSH and estrogen, to assess ovarian reserve
- measurements of thyroid functionthyroid stimulating hormone(TSH) level of between 1 and 2 is considered optimal for conception)
- measurement of progesterone in the second half of the cycle to help confirm ovulation
- Anti-Müllerian hormone to estimate ovarian reserve.[58]
- Examination and imaging
- an endometrial biopsy, to verify ovulation and inspect the lining of the uterus
- laparoscopy, which allows the provider to inspect the pelvic organs
- fertiloscopy, a relatively new surgical technique used for early diagnosis (and immediate treatment)
- Pap smear, to check for signs of infection
- pelvic exam, to look for abnormalities or infection
- a postcoital test, which is done soon after intercourse to check for problems with sperm surviving in cervical mucous (not commonly used now because of test unreliability)
- Hysterosalpingography or sonosalpingography, to check for tube patency
- Sonohysterographyto check for uterine abnormalities.
- an
There are genetic testing techniques under development to detect any mutation in genes associated with female infertility.[41]
Initial diagnosis and treatment of infertility is usually made by
Usually reproductive endocrinology & infertility medical practices do not see women for general
Prevention
Acquired female infertility may be prevented through identified interventions:
- Maintaining a healthy lifestyle. Excessive exercise, consumption of caffeine and alcohol, and smoking have all been associated with decreased fertility. Eating a well-balanced, nutritious diet, with plenty of fresh fruits and vegetables, and maintaining a normal weight, on the other hand, have been associated with better fertility prospects.
- Treating or preventing existing diseases. Identifying and controlling chronic diseases such as pap smears) help detect early signs of infections or abnormalities.
- Not delaying parenthood. Fertility does not ultimately cease before menopause, but it starts declining after age 27 and drops at a somewhat greater rate after age 35.premature menopause, that can be mitigated by not delaying parenthood.
- oocytes are cryogenically frozen and ready for her use later in life, reducing her chances of female infertility.[60]
Society and culture
Social stigma
Social stigma due to infertility is seen in many cultures throughout the world in varying forms. Often, when women cannot conceive, the blame is put on them, even when approximately 50% of infertility issues come from the man .[61] In addition, many societies only tend to value a woman if she is able to produce at least one child, and a marriage can be considered a failure when the couple cannot
Wealth is sometimes measured by the number of children a woman has, as well as inheritance of property.[62][65] Children can influence financial security in many ways. In Nigeria and Cameroon, land claims are decided by the number of children. Also, in some Sub-Saharan countries women may be denied inheritance if she did not bear any children [65] In some African and Asian countries a husband can deprive his infertile wife of food, shelter and other basic necessities like clothing.[65] In Cameroon, a woman may lose access to land from her husband and left on her own in old age.[62]
In many cases, a woman who cannot bear children is excluded from social and cultural events including traditional ceremonies. This stigmatization is seen in
The effect of infertility can lead to social shaming from internal and
Marital role
Men in some countries may find another wife when their first cannot produce a child, hoping that by sleeping with more women he will be able to produce his own child.[62][64][65] This can be prevalent in some societies, including Cameroon,[62][65] Nigeria,[62] Mozambique,[66] Egypt,[64] Botswana,[68] and Bangladesh,[65] among many more where polygamy is more common and more socially acceptable.
In some cultures, including Botswana [68] and Nigeria,[62] women can select a woman with whom she allows her husband to sleep with in hopes of conceiving a child.[62] Women who are desperate for children may compromise with her husband to select a woman and accept duties of taking care of the children to feel accepted and useful in society.[68]
Women may also sleep with other men in hopes of becoming pregnant.[66] This can be done for many reasons including advice from a traditional healer, or finding if another man was "more compatible". In many cases, the husband was not aware of the extra sexual relations and would not be informed if a woman became pregnant by another man.[66] This is not as culturally acceptable however, and can contribute to the gendered suffering of women who have fewer options to become pregnant on their own as opposed to men.[64]
Men and women can also turn to divorce in attempt to find a new partner with whom to bear a child. Infertility in many cultures is a reason for divorce, and a way for a man or woman to increase his/her chances of producing an heir.[62][64][66][68] When a woman is divorced, she can lose her security that often comes with land, wealth, and a family.[68] This can ruin marriages and can lead to distrust in the marriage. The increase of sexual partners can potentially result with the spread of disease including HIV/AIDS, and can actually contribute to future generations of infertility.[68]
Domestic abuse
The emotional strain and stress that comes with infertility in the household can lead to the mistreatment and
Mental and psychological impact
Many infertile women tend to cope with immense stress and
See also
- Infertility
- Male infertility
- Meiosis
- Oncofertility
- Primary infertility
- Secondary infertility
- Fertility
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