Cerebral venous sinus thrombosis

Cerebral venous sinus thrombosis (CVST), cerebral venous and sinus thrombosis or cerebral venous thrombosis (CVT), is the presence of a

Nine in ten people with cerebral venous thrombosis have a headache; this tends to worsen over the period of several days, but may also develop suddenly (thunderclap headache).^[3] The headache may be the only symptom.^[5] Many have symptoms of stroke: inability to move one or more limbs, weakness on one side of the face or difficulty speaking. The neurologic deficits related to central venous thromboses does not necessarily affect one side of the body or one arterial or brain territory as is more common "arterial" strokes.^[3][6] Bilateral 6th cranial nerve palsies may occur, causing abnormalities related to eye movement, but this is rare.^[6]

40% of people have

The pressure around the brain may rise, causing papilledema (swelling of the optic disc) which may be experienced as visual obscurations. In severely raised intracranial pressure, the level of consciousness is decreased, the blood pressure rises, the heart rate falls and there is abnormal posturing.^[3]

Focal neurologic deficits may occur hours to days after the headache in 50% of cases, this may present as hemiparesis (unilateral weakness) if due to infarction of the

Disorders that cause, or increase the risk for systemic venous thrombosis are associated with central venous thromboses.[6]^[9] In children, head and neck infections and acute systemic illnesses are the primary cause of central venous thrombosis.^[6] Cerebral venous sinus thrombosis is more common in particular situations. 85% of people have at least one of these risk factors:^[3]

• Thrombophilia, a tendency to develop blood clots due to abnormalities in coagulation, e.g. factor V Leiden, deficiency of protein C, protein S or antithrombin, or related problems
• Nephrotic syndrome, a kidney problem causing protein loss in the urine
• Chronic inflammatory diseases, such as inflammatory bowel disease, lupus and Behçet's disease
• puerperium
  (the period after giving birth)
• Particular blood disorders, especially polycythemia vera and paroxysmal nocturnal hemoglobinuria
• Use of estrogen-containing forms of hormonal contraception
• Meningitis and infections of the ear, nose and throat area such as mastoiditis and sinusitis
• Direct injury to the venous sinuses
• Medical procedures in the head and neck area
• Obesity, especially in combination with oral contraceptive use ^[10]
• Sickle cell anemia
• Dehydration, primarily in infants and children
• Homocysteinemia
• Homocystinuria

Diagnosis

The diagnosis may be suspected on the basis of the symptoms, for example the combination of headache, signs of raised intracranial pressure and focal neurological abnormalities, or when alternative causes of headache and neurological abnormalities, such as a subarachnoid hemorrhage, have been excluded.^[3]

Imaging

There are various

Magnetic resonance venography employs the same principles, but uses MRI as a scanning modality. MRI has the advantage of being better at detecting damage to the brain itself as a result of the increased pressure on the obstructed veins, but it is not readily available in many hospitals and the interpretation may be difficult.^[11]

Cerebral angiography may demonstrate smaller clots than CT or MRI, and obstructed veins may give the "corkscrew appearance".^[3] This, however, requires puncture of the femoral artery with a sheath and advancing a thin tube through the blood vessels to the brain where radiocontrast is injected before X-ray images are obtained. It is therefore only performed if all other tests give unclear results or when other treatments may be administered during the same procedure.

D-dimer

There is an association between the D-dimer blood test and cerebral venous sinus thrombosis.^[12] This association however is not strong enough to rule out the diagnosis alone.^[12]

Further tests

In most cases, the direct cause for the cerebral sinus thrombosis is not readily apparent. Identifying a source of infection is crucial; it is common practice to screen for various forms of thrombophilia (a propensity to form blood clots).^[3]

Pathogenesis

The veins of the brain, both the superficial veins and the deep venous system, empty into the dural venous sinuses, which carry blood back to the jugular vein and thence to the heart. In cerebral venous thrombosis, blood clots usually form both in the veins of the brain and the venous sinuses. The thrombosis of the veins themselves causes venous infarction (damage to brain tissue due to a congested and therefore insufficient blood supply). This results in cerebral edema (both vasogenic and cytotoxic edema), and leads to small petechial haemorrhages that may merge into large haematomas. Thrombosis of the sinuses is the main mechanism behind the increase in intracranial pressure due to decreased resorption of cerebrospinal fluid (CSF). The condition does not typically lead to hydrocephalus, however, because there is no difference in pressure between various parts of the brain.^[3] However, those who have deep cerebral venous sinus thrombosis or oedema at basal ganglia are more prone to hydrocephalus development.^[13]

Any blood clot forms due to an imbalance between coagulation (the formation of the insoluble blood protein fibrin) and fibrinolysis. The three major mechanisms for such an imbalance are enumerated in Virchow's triad: alterations in normal blood flow, injury to the blood vessel wall, and alterations in the constitution of blood (hypercoagulability). Most cases of cerebral venous sinus thrombosis are due to hypercoagulability.^[3] The inflammatory response and prolonged immobilization of patients with COVID-19 may also help explain the formation of CVST.^[14]

It is possible for the clot to break off and migrate (embolise) to the lungs, causing a pulmonary embolism.^[3][7] An analysis of earlier case reports concludes that this occurs in about 10% of cases, but has a very poor prognosis.^[15]

Central venous thromboses usually involve the dural sinuses with or without involvement of the cortical veins; isolated cortical venous thromboses are extremely rare with only about 100 cases reported.^[6]

Treatment

Various studies have investigated the use of

The duration of warfarin treatment depends on the circumstances and underlying causes of the condition. If the thrombosis developed under temporary circumstances (e.g. pregnancy), three months are regarded as sufficient. If the condition was unprovoked but there are no clear causes or a "mild" form of thrombophilia, 6 to 12 months is advised. If there is a severe underlying thrombosis disorder, warfarin treatment may need to continue indefinitely.[7]

Heparin and platelet transfusions should not be used as a treatment for any form of cerebral venous thrombosis caused by immune thrombotic thrombocytopenias including

Thrombolysis (removal of the blood clot with "clot buster" medication) has been described, either systemically by injection into a vein or directly into the clot during angiography. The 2006 European Federation of Neurological Societies guideline recommends that thrombolysis is only used in people who deteriorate despite adequate treatment, and other causes of deterioration have been eliminated. It is unclear which drug and which mode of administration is the most effective. Bleeding into the brain and in other sites of the body is a major concern in the use of thrombolysis.^[7] American guidelines make no recommendation with regards to thrombolysis, stating that more research is needed.^[18]

In those where a venous infarct or hemorrhage causes significant compression of surrounding brain structures, decompressive craniectomy is sometimes required.^[20] Raised intracranial pressure, if severe or threatening vision, may require therapeutic lumbar puncture (removal of excessive cerebrospinal fluid), or neurosurgical treatment (optic nerve sheath fenestration or shunting).^[3] Venous stenting is emerging as a minimally invasive, safer alternative to shunting.^[21] In certain situations, anticonvulsants may be used to try to prevent seizures.^[7] These situations include focal neurological problems (e.g. inability to move a limb) and focal changes of the brain tissue on CT or MRI scan.^[7] Evidence to support or refute the use of antiepileptic drugs as a preventive measure, however, is lacking.^[22]

Prognosis

In 2004 the first adequately large scale study on the natural history and long-term prognosis of this condition was reported; this showed that at 16 months follow-up 57.1% of people had full recovery, 29.5%/2.9%/2.2% had respectively minor/moderate/severe symptoms or impairments, and 8.3% had died. Severe impairment or death were more likely in those aged over 37 years, male, affected by coma, mental status disorder, intracerebral hemorrhage, thrombosis of the deep cerebral venous system, central nervous system infection and cancer.^[23] A subsequent systematic review of nineteen studies in 2006 showed that mortality is about 5.6% during hospitalisation and 9.4% in total, while of the survivors 88% make a total or near-total recovery. After several months, two thirds of the cases has resolution ("recanalisation") of the clot. The rate of recurrence was low (2.8%).^[24]

In children with CVST the risk of death is high.^[25] Poor outcome is more likely if a child with CVST develops seizures or has evidence of venous infarction on imaging.^[26]

Epidemiology

Cerebral venous sinus thrombosis is rare, with an estimated 3-4 cases per million annual incidence in adults. While it may occur in all age groups, it is most common in the third decade. 75% are female.^[7] Given that older studies show no difference in incidence between men and women, it has been suggested that the use of oral contraceptives in women is behind the disparity between the sexes.^[3] A 1995 report from Saudi Arabia found a substantially larger incidence at 7 cases per 100,000; this was attributed to the fact that Behçet's disease, which increases risk of CVST, is more common in the Middle East.^[27]

A 1973 report found that CVST could be found on autopsy (examination of the body after death) in nine percent of all people. Many of these were elderly and had neurological symptoms in the period leading up to their death, and many developed concomitant heart failure.^[28] An estimated 0.3% incidence of CVST in patients infected with SARS-CoV-2.^[14]

In children, a Canadian study reported in 2001 that CVST occurs in 6.7 per million annually. 43% occur in the newborn (less than one month old), and a further 10% in the first year of life. Of the newborn, 84% were already ill, mostly from complications after childbirth and dehydration.^[26]

History

The first description of thrombosis of the cerebral veins and sinuses is attributed to the French physician Ribes, who in 1825 observed thrombosis of the sagittal sinus and cerebral veins in a man who had had seizures and delirium.^[29] Until the second half of the 20th century it remained a diagnosis generally made after death.^[30] In the 1940s, reports by Dr Charles Symonds and others allowed for the clinical diagnosis of cerebral venous thrombosis, using characteristic signs and symptoms and results of lumbar puncture.^[31][32]

Improvements on the diagnosis of cerebral venous sinus thrombosis in life were made with the introduction of venography in 1951,^[33] which also aided in the distinction from idiopathic intracranial hypertension,^[34] which has similar presenting signs and symptoms in many cases.^[30]

The British gynecologist Stansfield is credited with the introduction, in 1942, of the just recently introduced anticoagulant heparin in the treatment of CVST in 1942.^[30][32] Clinical trials in the 1990s finally resolved the concern about using anticoagulants in most cases of CVST.^[7]

COVID-19 vaccine

In March 2021, the European Medicines Agency (EMA) announced that out of the around 20 million people who had received the Oxford–AstraZeneca COVID-19 vaccine, general blood clotting rates were normal, but that it had identified seven cases of disseminated intravascular coagulation, and eighteen cases of cerebral venous sinus thrombosis.^[35] It had been proposed that inadvertent injection of COVID-19 vaccine into deltoid muscle vasculature may result in vaccine distribution to distant tissues that may be causing these rare adverse reactions.^[36] A causal link with the vaccine, however, had not been proven, but the EMA decided to conduct further analysis and to inform recipients of the remote possibility of such rare syndromes.^[35] EMA confirmed that the vaccine's benefits still outweigh the risks^[35] and later released updated product information.^[37][38][39] and issued warnings to patients and healthcare professionals.^[40] The British Medicines and Healthcare products Regulatory Agency (MHRA) confirmed 79 cases of thrombosis, including 19 fatalities, within the first 20 million vaccinations in Great Britain.^{[41] [42]} Guidelines on management of suspected cases was issued by the British Society for Haematology; it discouraged the use of heparin until it was clearer that heparin would not aggravate the thrombosis.^[43] On 13 April 2021 the Centers for Disease Control and Prevention paused the use of the Janssen COVID-19 vaccine in the United States due to six cases of CVST that occurred 6 to 13 days after administration.^[44] The recommended pause was lifted on 23 April 2021 following a safety review.^[45]

Notable cases

U.S. Secretary of State

External links

Wikimedia Commons has media related to Cerebral venous sinus thrombosis.

• "Intracranial venous thrombosis – Patient UK". Archived from the original on 12 May 2008. Retrieved 28 October 2007.
• UCH Institute for Child Health. "Clinical guideline Cerebral Venous Sinus Thrombosis in Children". Archived from the original on 2 February 2009. Retrieved 28 October 2007.