Zinc transporter 1
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SLC30A1
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| Location (UCSC) | Chr 1: 211.57 – 211.58 Mb | Chr 1: 191.64 – 191.65 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene.[5][6]
Function
SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation.[7]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000170385 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037434 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7882967.
- PMID 15154973.
- PMID 15451416.
Further reading
- Guey LT, GarcÃa-Closas M, Murta-Nascimento C, et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes". Eur. Urol. 57 (2): 283–292. PMID 19692168.
- Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. S2CID 33951242.
- Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity Research. 7 (4): 265–71. S2CID 11433.
- Zhang LY, Wang XL, Sun DX, et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts". Mol. Biol. Rep. 35 (4): 595–600. S2CID 2490974.
- Iguchi K, Otsuka T, Usui S, et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. PMID 14662799.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.
- Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. PMID 18158319.
- Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. S2CID 21801798.
- Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory Medicine. 103 (12): 1866–1870. PMID 19625176.
- Hosgood HD, Menashe I, Shen M, et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. PMID 18676680.
- Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. S2CID 8430908.
- Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. PMID 18029348.
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