Estrogenic substances

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Not to be confused with Estrogen (medication) or Estrone (medication).
Estrogenic substances
oil solution)
Drug classEstrogen
Legal status
Legal status

Estrogenic substances, also referred to as natural estrogens and sold under the brand name Amniotin among others, is an

crystalline mixture of estrogens, including estrone, 17β-estradiol, 17α-estradiol, and/or equilin.[3][1][7][8][5][9] The medication was thought to contain estrone as its major active ingredient[7] and was described as an estrone-like preparation, or as "essentially estrone".[1][3][5] Estrogenic substances was originally produced from the urine of pregnant women, placenta, and/or amniotic fluid, but by the early 1940s, it was manufactured exclusively from the urine of stallions or pregnant mares, similarly to almost all other estrogen preparations on the market.[8][9][7][1]

Estrogenic substances was marketed under a variety of different brand names including Amniotin (

ointments.[2][3][4][1][6]

Estrogen medications similar to but distinct from estrogenic substances included conjugated estriol (Emmenin) and conjugated estrogens (Premarin).[1] They are also non-crystalline mixtures of estrogens.[1] Estrogenic substances were also distinct from pure crystalline preparations such as estrone, estradiol, estriol, estradiol benzoate, and estradiol dipropionate.[1] The medication should additionally be distinguished from estrogen ovarian extracts, which had little activity and were considered to be essentially inactive.[10][2]

Progynon and Amniotin were both marketed by 1929.[11] Amniotin was originally prepared from the amniotic fluid of cattle, but was later prepared using other sources such as the urine of pregnant mares.[12][9]

References

  1. ^
    ISSN 0002-9955
    .
  2. ^
    PMID 18744783
    .
  3. ^
    ISSN 0025-7125
    .
  4. ^
    ISSN 0002-9955
    .
  5. ^
    ISSN 0025-7125
    .
  6. ^ a b c Goldzieher MA, Goldzieher JW (1953). Endocrine Treatment in General Practice. Springer Publishing Company. pp. 436–.
  7. ^
    ISBN 9780598668332
    . Complex Estrogenic Preparations. 1. Amniotin (Squibb). This is a highly purified but not crystalline preparation derived from pregnant mares' urine. The chief active ingredient is apparently ketohydroxyestrin (estrone).
  8. ^ a b Glandular Physiology and Therapy. American Medical Association. 1935. p. 480. Amniotin, E. R. Squibb & Sons: This is an estrogenic preparation originally derived from amniotic fluid; it is not reduced to the crystalline state during manufacture. More recently, according to the firm, the urine of pregnant mares has served as an added source of active material.
  9. ^
    doi:10.3949/ccjm.2.4.52
    .
  10. ISSN 0098-7484
    .
  11. ^ The Female Sex Hormone. C.C. Thomas. 1929. p. 276.
  12. ISSN 0002-9955
    .
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