Fenbufen

Source: Wikipedia, the free encyclopedia.
Fenbufen
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • UK: POM (Prescription only)
Identifiers
  • 4-(4-Biphenylyl)-4-oxobutanoic acid
    or
    4-Oxo-4-(4-phenylphenyl)butanoic acid
JSmol)
Melting point186 °C (367 °F)
  • O=C(O)CCC(=O)c2ccc(c1ccccc1)cc2
  • InChI=1S/C16H14O3/c17-15(10-11-16(18)19)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-9H,10-11H2,(H,18,19) checkY
  • Key:ZPAKPRAICRBAOD-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fenbufen is a nonsteroidal anti-inflammatory drug used to treat pain.[1]

Fenbufen is a member of the propionic acid derivatives class of drugs.[2]

It was introduced by American Cyanamid under the trade name Lederfen in the 1980s. Due to liver toxicity, it was withdrawn from markets in the developed world in 2010.[3][4]: 370, 383–384 

As of 2015 it was available in Taiwan and Thailand under several brand names.[5]

Preparation

Fenbufen can be synthesized by acylation of

Friedel-Crafts conditions.[6]

References

  1. PMID 19821427
    .
  2. S2CID 25471102
    .
  3. ^ "Deleted products 2010". Monthly Index of Medical Specialities (MIMS). Haymarket Media Group Ltd.
  4. ISBN 978-0-12-387818-2
    .
  5. ^ "International listings for fenbufen". Drugs.com. Retrieved 25 June 2015.
  6. doi:10.1080/00304949509458497
    .
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