Mofezolac

Source: Wikipedia, the free encyclopedia.
Mofezolac
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • [3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetic acid
JSmol)
  • COC1=CC=C(C=C1)C2=C(ON=C2C3=CC=C(C=C3)OC)CC(=O)O
  • InChI=1S/C19H17NO5/c1-23-14-7-3-12(4-8-14)18-16(11-17(21)22)25-20-19(18)13-5-9-15(24-2)10-6-13/h3-10H,11H2,1-2H3,(H,21,22)
  • Key:DJEIHHYCDCTAAH-UHFFFAOYSA-N
  (verify)

Mofezolac (

INN), sold under the name Disopain in Japan, is a nonsteroidal anti-inflammatory drug (NSAID) used for its analgesic and anti-inflammatory actions. It is often prescribed for rheumatoid arthritis, lower back pain, frozen shoulder, and pain management after surgery or trauma.[1] It is also being investigated for potential use in the treatment of neuroinflammation.[2][3]

Common side effects include

asthma attack, jaundice, acute liver failure, and thrombocytopenia.[1] Use is not recommended during pregnancy or breastfeeding.[4]

Mofezolac acts via selective inhibition of the

COX-1 and consequent suppression of prostaglandin synthesis.[5] It is the most potent and selective reversible COX-1 inhibitor.[6] Studies of ovine COX-1 in complex with mofezolac indicate that the drug forms a combination of electrostatic, H-bond, hydrophobic, and van der Waals contacts with the enzyme active site channel, contributing to mofezolac's high binding affinity.[7]

Mofezolac belongs to the class of isoxazoles and is a substrate of CYP2C9.[8]

It is manufactured and marketed by Nipro ES Pharma Co., Ltd.[1]

References

  1. ^ a b c "Kusuri-no-Shiori (Drug Information Sheet)". RAD-AR Council, Japan. June 2018. Retrieved 2021-10-18.
  2. PMID 22001217
    .
  3. PMID 28649222
    .
  4. ^ "Pharmaceuticals and Medical Devices Safety Information" (381). Translated by Pharmaceuticals and Medical Devices Agency. Japan Ministry of Health, Labour and Welfare. March 2021. {{cite journal}}: Cite journal requires |journal= (help)
  5. PMID 2109726
    .
  6. S2CID 58648199
    .
  7. PMID 28710965
    .
  8. ^ "DRUG: Mofezolac". KEGG. Retrieved 2021-10-18.
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