Droxicam

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Droxicam
Skeletal formula of droxicam
Space-filling model of the droxicam molecule
Clinical data
ATC code
Identifiers
  • 2H,5H-1,3-Oxazino(5,6-c)(1,2)benzothiazine-2,4(3H)-dione, 5-methyl-3-(2-pyridinyl)-, 6,6-dioxide
JSmol)
SMILES
  • CN1c2c(oc(=O)n(c2=O)c3ccccn3)-c4ccccc4S1(=O)=O
  • InChI=1S/C16H11N3O5S/c1-18-13-14(10-6-2-3-7-11(10)25(18,22)23)24-16(21)19(15(13)20)12-8-4-5-9-17-12/h2-9H,1H3 checkY
  • Key:OEHFRZLKGRKFAS-UHFFFAOYSA-N checkY

Droxicam is a

musculoskeletal disorders such as rheumatoid arthritis and osteoarthritis.[1]

Synthesis

When heated, phenyl pyridin-2-ylcarbamate (1) decomposes to 2-isocyanatopyridine (2) which reacts with the heterocyclic compound (3) to give droxicam.[2][3][4]

References

  1. PMID 1365488
    .
  2. ^ US patent 4563452, Jose M. Ribalta-Baro and Jordi F. Rigola-Constansa, "Benzothiazine derivatives and their applications as medicinal products or as synthesis intermediates for medicinal products", issued 1992-07-21, assigned to Laboratorios del Dr Esteve SA 
  3. ^ "Droxicam". Thieme. Retrieved 2024-07-04.
  4. ^ "Droxicam". chemdrug.com. Retrieved 2024-07-04.
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