List of progestogens available in the United States
This is a list of
gynecological disorders.[medical citation needed
]
For contraception
Combined contraceptives
Combined oral contraceptive pills
- Drospirenone and Estetrol (Nextstellis)
- Estradiol valerate and dienogest (Natazia)
- Ethinylestradiol and desogestrel (Bekyree, Cyclessa, Desogen, Emoquette, Enskyce, Isibloom, Kariva, Kimidess, Mircette, Ortho-Cept, Pimtrea, Velivet, Viorele, Volnea)
- levomefolate calcium] (Beyaz, Loryna, Melamisa, Nikki, Safyral, Syeda, Yaela, Yasmin, Yaz)
- Ethinylestradiol and etynodiol diacetate (Demulen 1/35-21, Demulen 1/35-28, Demulen 1/50-21, Demulen 1/50-28, Kelnor, Zovia 1/35E-21, Zovia 1/35E-28, Zovia 1/50E-21, Zovia 1/50E-28)
- Ethinylestradiol and levonorgestrel (Alesse, Altavera, Ashlyna, Aviane-21, Aviane-28, Ayuna, Daysee, Elifemme, Enpresse-21, Enpresse-28, Falmina, Fayosim, Introvale, Kurvelo, Lessina-21, Lessina-28, Levlite, Levonest, Levonorgestrel and Ethinyl Estradiol, Levora 0.15/30-21, Levora 0.15/30-28, LoSeasonique, Lybrel, Marlissa, Myzilra, Nordette-21, Nordette-28, Orsythia, Portia-21, Portia-28, Preven Emergency Contraceptive Kit, Quartette, Quasense, Seasonale, Seasonique, Setlakin, Triphasil-21, Triphasil-28, Trivora-21, Trivora-28, Vienva)
- ferrous fumarate(Fe)] (Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Aranelle, Balziva-21, Balziva-28, Brevicon 21-Day, Brevicon 28-Day, Briellyn, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Dasetta 1/35, Dasetta 7/7/7, Femcon Fe, Gencept 10/11-21, Gencept 10/11-28, Gildagia, Kaitlib Fe, Modicon 21, Modicon 28, N.E.E. 1/35 21, N.E.E. 1/35 28, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
- ferrous fumarate (Fe)] (Activella, Alyacen 1/35, Alyacen 7/7/7, Alyacen 777, Amabelz, Aranelle, Aurovela 1.5/30,[1] Aurovela 1/20,[2] Aurovela 24 Fe,[3] Aurovela Fe 1.5/30,[4] Aurovela Fe 1/20,[5] Aurovela Fe,[6] Aygestin, Balziva-21, Balziva-28, Blisovi 24 Fe,[7] Blisovi Fe 1.5/30,[8] Blisovi Fe 1/20,[9] Brevicon 21-Day, Brevicon 28-Day, Briellyn, Camila, Chabelina Fe,[10] Charlotte 24 Fe,[11] Combipatch, Cyclafem 0.5/35, Cyclafem 1/35, Cyclafem 7/7/7, Cyonanz, Dasetta 1/35, Dasetta 7/7/7, Errin, Estrostep 21,[12] Estrostep Fe,[13] Femcon Fe, Femhrt,[14] Finzala,[15] Fyavolv,[16] Gemmily,[17] Gencept 10/11-21, Gencept 10/11-28, Gildagia, Gildess 1.5/30,[18] Gildess 1/20,[19] Gildess 24 Fe,[20] Gildess Fe 1.5/30,[21] Gildess Fe 1/20,[22] Hailey 1.5/30,[23] Hailey 24 Fe,[24] Hailey Fe 1.5/30,[23] Hailey Fe 1/20,[25] Heather, Incassia, Jencycla, Jinteli,[26] Junel 1.5/30,[27] Junel 1/20, Junel 21,[28] Junel Fe 1.5/30,[27] Junel Fe 1/20,[29] Junel Fe 24,[30] Junel Fe 28,[28] Kaitlib Fe, Larin 1.5/30,[31] Larin 1/20,[32] Larin 24 Fe,[33] Larin Fe 1.5/30,[34] Larin Fe 1/20,[35] Leribane, Lo Larin Fe, Lo Loestrin Fe,[36] Lo Minastrin Fe, Lo-Blisovi Fe, Loestrin 21 1.5/30, Loestrin 21 1/20, Loestrin 21,[37] Loestrin 24 Fe,[38] Loestrin Fe 1.5/30, Loestrin Fe 1/20, Loestrin Fe 28,[37] Lomedia 24 Fe,[39] Lupaneta Pack, Melodetta 24 Fe,[40] Merzee,[41]Mibelas 24 Fe, Microgestin 1.5/30, Microgestin 1/20, Microgestin Fe 1.5/30, Microgestin Fe 1/20, Micronor, Minastrin 24 Fe, Modicon 21, Modicon 28, Myfembree, N.E.E. 1/35 21, N.E.E. 1/35 28, Nexesta Fe, Nor-Qd, Norcept-E 1/35 21, Norcept-E 1/35 28, Norethin 1/35E-21, Norethin 1/35E-28, Norethin 1/50M-21, Norethin 1/50M-28, Norinyl, Norinyl 1+35 21-Day, Norinyl 1+35 28-Day, Norinyl 1+50 21-Day, Norinyl 1+50 28-Day, Norinyl 1+80 21-Day, Norinyl 1+80 28-Day, Norlestrin 21 1/50, Norlestrin 21 2.5/50, Norlestrin 28 1/50, Norlestrin Fe 1/50, Norlestrin Fe 2.5/50, Norlutate, Norlutin, Norminest Fe, Norquest Fe, Nortrel 0.5/35-21, Nortrel 0.5/35-28, Nortrel 1/35-21, Nortrel 1/35-28, Nortrel 7/7/7, Nylia 1/35, Nylia 7/7/7, Oriahnn (Copackaged), Ortho-Novum 1/35-21, Ortho-Novum 1/35-28, Ortho-Novum 1/50 21, Ortho-Novum 1/50 28, Ortho-Novum 1/80 21, Ortho-Novum 1/80 28, Ortho-Novum 2-21, Ortho-Novum 7/7/7-21, Ortho-Novum 7/7/7-28, Ortho-Novum 7/14-21, Ortho-Novum 7/14-28, Ortho-Novum 10-21, Ortho-Novum 10/11-21, Ortho-Novum 10/11-28, Ovcon-35, Ovcon-50, Philith, Pirmella 1/35, Pirmella 7/7/7, Taytulla, Tri-Legest 21, Tri-Legest 21 , Tri-Legest Fe, Tri-Norinyl 21-Day, Tri-Norinyl 28-Day, Vyfemla, Wera)
- Ethinylestradiol and norgestimate (Estarylla, Mili, Mono-Linyah, Ortho Cyclen-21, Ortho Cyclen-28, Ortho Tri-Cyclen, Ortho Tri-Cyclen 21, Ortho Tri-Cyclen 28, Ortho Tri-Cyclen Lo, Previfem, Sprintec, Tri Lo Sprintec, Tri-Estarylla, Tri-Linyah, Tri-Lo-Estarylla, Tri-Lo-Linyah, Tri-Mili, Tri-Previfem, Tri-Sprintec)
- Ethinylestradiol and norgestrel (Cryselle, Elinest, Lo/Ovral, Lo/Ovral-28, Low-Ogestrel-21, Low-Ogestrel-28, Ogestrel 0.5/50-21, Ogestrel 0.5/50-28, Ovral, Ovral-28)
- Mestranol and norethisterone (Norinyl 1+50 28-Day)
Transdermal patches
- Ethinylestradiol and norelgestromin (Ortho Evra, Xulane)
Vaginal rings
- NuvaRing)
- Ethinylestradiol and segesterone acetate (Annovera)
Combined injectable contraceptives
Estradiol cypionate and medroxyprogesterone acetate (Lunelle; 5 mg / 25 mg) was previously available in the U.S. but was discontinued.
Progestogen-only contraceptives
Progestogen-only pills
- Drospirenone (Slynd) – 4 mg (available as of 2019)[42]
- Norethisterone (Camila, Errin, Heather, Incassia, Jencycla, Micronor, Nor-QD) – 0.35 mg
- Norgestrel (Opill) – 0.075 mg (available over-the-counter as of 2023)[43]
Norgestrel (Ovrette; 0.075 mg) was also previously available in the U.S. as a prescription, but was discontinued in 2005 due to "marketing reasons".[44]
Postcoital emergency contraceptive pills
- Levonorgestrel (Athentia Next, Fallback Solo, Her Style, Opcicon One-Step, Plan B, Plan B One-Step) – 0.75 mg, 1.5 mg
Progestogen-only injectable contraceptives
- Medroxyprogesterone acetate (Depo-Provera) – 150 mg/mL (intramuscular)
- Medroxyprogesterone acetate (Depo-SubQ Provera 104) – 104 mg/0.65 mL (subcutaneous)
Intrauterine devices
- Levonorgestrel (Kyleena, Liletta, Mirena, Skyla) – 13.5 mg/device, 19.5 mg/device, 52 mg/device
Progesterone (Progestasert; 38 mg/device) was previously available in the U.S. but was discontinued.
Subcutaneous implants
- Etonogestrel (Implanon, Nexplanon) – 68 mg/implant
- Levonorgestrel (Jadelle, Norplant, Norplant System in Plastic Container) – 36 mg/implant, 75 mg/implant
For other uses
Combined with estrogen
Oral pills
- Conjugated estrogens and medroxyprogesterone acetate(Premphase (Premarin, Cycrin 14/14), Premphase 14/14, Prempro, Prempro (Premarin, Cycrin), Prempro/Premphase) – 0.3 mg / 1.5 mg; 0.45 mg / 1.5 mg; 0.625 mg / 2.5 mg; 0.625 mg / 5 mg
- Estradiol and drospirenone (Angeliq) – 0.5 mg / 0.25 mg; 1 mg / 0.5 mg
- Estradiol and norethisterone acetate (Activella, Amabelz) – 1 mg / 0.5 mg; 0.5 mg / 0.1 mg
- Ethinylestradiol and norethisterone acetate (FemHRT) – 25 μg / 0.5 mg
Estradiol/progesterone (TX-001HR), a combination of estradiol and progesterone in oil-filled capsules, is currently pending approval.[45]
Estradiol and norgestimate (Prefest; 1 mg / 90 μg) was previously available in the U.S. but was discontinued.
Transdermal patches
- Estradiol and levonorgestrel (Climara Pro) – 45 μg/24 hours / 15 μg/24 hours
- Estradiol and norethisterone acetate (Combipatch) – 50 μg/24 hours / 0.14 mg/24 hours; 50 μg/24 hours / 0.25 mg/24 hours
Progestogen-only
Oral pills
- Medroxyprogesterone acetate (Amen, Curretab, Cycrin, Provera) – 2.5 mg, 5 mg, 10 mg
- AIDS[47]
- Norethisterone acetate (Aygestin, Norlutate) – 5 mg
- Progesterone (Prometrium) – 100 mg, 200 mg, 300 mg
Atypical:
- Danazol (Danocrine) – 50 mg, 100 mg, 200 mg – approved specifically for the treatment of endometriosis
Oral suspensions
- AIDS
Vaginal tablets
- Progesterone (Endometrin) – 100 mg
Vaginal gels
- Progesterone (Crinone) – 4%, 8%
Intramuscular injectables
- Hydroxyprogesterone caproate (Delalutin, Makena, Makena Preservative Free) – 125 mg/mL, 250 mg/mL
- Medroxyprogesterone acetate (Depo-Provera) – 400 mg/mL – approved specifically for the treatment of endometrial/renal cancer
- Progesterone (Progesterone) – 50 mg/mL (25 mg/mL discontinued)
Miscellaneous
- Norethisterone acetate and leuprorelin (Lupaneta Pack) – 5 mg norethisterone acetate oral pills, 3.75 mg/vial, 11.25 mg/vial leuprorelin for intramuscular injection – approved specifically for the treatment of painful endometriosis
Not available in the United States
- Acetomepregenol
- Algestone acetophenide
- Allylestrenol
- Chlormadinone acetate
- Cyproterone acetate
- Demegestone
- Dimethisterone
- Dydrogesterone
- Ethisterone
- Gestodene
- Gestonorone caproate
- Gestrinone
- Haloprogesterone
- Hydroxyprogesterone acetate
- Hydroxyprogesterone heptanoate
- Lynestrenol
- Medrogestone
- Nomegestrol acetate
- Norethisterone enanthate
- Noretynodrel
- Norgesterone
- Norgestrienone
- Normethandrone
- Norvinisterone
- Oxendolone
- Pentagestrone acetate
- Promegestone
- Quingestanol acetate
- Quingestrone
- Segesterone acetate
- Tibolone
- Trengestone
- Trimegestone
See also
- List of sex-hormonal medications available in the United States
- List of progestogens
- List of progestogen esters
- Oral contraceptive formulations
- Estradiol-containing oral contraceptive
References
- ^ "Aurovela 1.5/30- norethindrone acetate and ethinyl estradiol tablet". DailyMed.
- ^ "Aurovela 1/20- norethindrone acetate and ethinyl estradiol tablet". DailyMed.
- ^ "Aurovela 24 FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Aurovela Fe 1.5/30: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA).
- ^ "Aurovela FE 1/20- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Aurovela FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Blisovi 24 FE- norethindrone acetate and ethinyl estradiol kit". DailyMed.
- ^ "Blisovi FE 1.5/30- norethindrone acetate and ethinyl estradiol kit". DailyMed.
- ^ "Blisovi FE 1/20- norethindrone acetate and ethinyl estradiol kit". DailyMed.
- ^ "Chabelina Fe: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA).
- ^ "Charlotte 24FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Estrostep 21: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA).
- ^ "Estrostep FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Femhrt- norethindrone acetate/ethinyl estradiol tablet". DailyMed.
- ^ "Finzala: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA).
- ^ "Fyavolv- norethindrone acetate and ethinyl estradiol tablet, film coated". DailyMed.
- ^ "Gemmily- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit". DailyMed.
- ^ "Gildess 1.5/30 (norethindrone acetate and ethinyl estradiol tablets, USP)". DailyMed.
- ^ "Gildess 1/20 (norethindrone acetate and ethinyl estradiol tablets, USP)". DailyMed.
- ^ "Gildess 24 Fe (norethindrone acetate and ethinyl estradiol tablets, USP)". DailyMed.
- ^ "Gildess Fe 1.5/30 (norethindrone acetate and ethinyl estradiol tablets, USP)". DailyMed.
- ^ "Gildess Fe 1/20 (norethindrone acetate and ethinyl estradiol tablets, USP)". DailyMed.
- ^ a b "Hailey FE 1.5/30- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Hailey 24 FE- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit". DailyMed.
- ^ "Hailey FE 1/20- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Jinteli- norethindrone acetate and ethinyl estradiol tablet". DailyMed.
- ^ a b "Junel FE 1.5/30- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit". DailyMed.
- ^ a b "Junel 21 DAY- norethindrone acetate and ethinyl estradiol tablet JUNEL FE 28 DAY- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Junel FE 1/20- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit". DailyMed.
- ^ "Junel FE 24- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Larin 1.5/30- norethindrone acetate/ethinyl estradiol kit". DailyMed.
- ^ "Larin 1/20- norethindrone acetate/ethinyl estradiol kit". DailyMed.
- ^ "Larin 24 FE- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Larin FE 1.5/30- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Larin FE 1/20- norethindrone acetate/ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Lo Loestrin FE- norethindrone acetate and ethinyl estradiol, ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ a b "Loestrin 21 DAY- norethindrone acetate and ethinyl estradiol tablet Loestrin FE 28 DAY- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Loestrin 24 FE- norethindrone acetate and ethinyl estradiol, and ferrous fumarate kit". DailyMed.
- ^ "Lomedia 24 FE- norethindrone acetate and ethinyl estradiol kit". DailyMed.
- ^ "Melodetta 24 FE- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ "Merzee- norethindrone acetate and ethinyl estradiol and ferrous fumarate kit". DailyMed.
- ^ Brian Park, PharmD (16 September 2019). "Slynd, a Progestin-Only Contraceptive, Now Available". Monthly Prescribing Reference (MPR). Haymarket Media, Inc. Retrieved 5 January 2020.
- ^ Commissioner, Office of the (2023-07-13). "FDA Approves First Nonprescription Daily Oral Contraceptive". FDA. Retrieved 2024-03-17.
- ^ Murry, Karen (July 13, 2023). "Decisional Memorandum New Drug Application 17031 Supplement 41 Application for Full Prescription-to-Nonprescription Switch of Norgestrel Tablets 0.075 mg" (PDF). FDA.
- PMID 25944519.
- ISBN 978-0-7817-9558-6.
- ISBN 978-2-88919-468-1.
In 1993, the Food and Drug Administration (FDA) approved megestrol acetate for the treatment of cancer anorexia-cachexia syndrome as well as cachexia due to chronic conditions, including human acquired immunodeficiency syndrome (AIDS).