SARS-CoV-2 Eta variant

Source: Wikipedia, the free encyclopedia.

Countries with confirmed cases of Eta variant as of 1 July 2021 (GISAID)
Legend:
  1000+ confirmed sequences
  500–999 confirmed sequences
  100–499 confirmed sequences
  10–99 confirmed sequences
  2–9 confirmed sequences
  1 confirmed sequence
  None or no data available

The Eta variant is a variant of SARS-CoV-2, the virus that causes COVID-19. The Eta variant or lineage B.1.525, also called VUI-21FEB-03 (previously VUI-202102/03) by Public Health England (PHE) and formerly known as UK1188, 21D or 20A/S:484K, does not carry the same N501Y mutation found in Alpha, Beta and Gamma, but carries the same E484K-mutation as found in the Gamma, Zeta, and Beta variants, and also carries the same ΔH69/ΔV70 deletion (a deletion of the amino acids histidine and valine in positions 69 and 70) as found in Alpha, N439K variant (B.1.141 and B.1.258) and Y453F variant (Cluster 5).[1]

Eta differs from all other variants by having both the E484K-mutation and a new F888L mutation (a substitution of phenylalanine (F) with leucine (L) in the S2 domain of the spike protein). As of 5 March 2021, it had been detected in 23 countries.[2][3][4] It has also been reported in Mayotte, the overseas department/region of France.[2] The first cases were detected in December 2020 in the UK and Nigeria, and as of 15 February, it had occurred in the highest frequency among samples in the latter country.[4] As of 24 February, 56 cases were found in the UK. Denmark, which sequences all its COVID-19 cases, found 113 cases of this variant from January 14 to February 21, of which seven were directly related to foreign travels to Nigeria.[3]

UK experts are studying it to understand how much of a risk it could be. It is currently regarded as a "variant under investigation", but pending further study, it may become a "variant of concern". Prof Ravi Gupta, from the University of Cambridge spoke to the BBC and said lineage B.1.525 appeared to have "significant mutations" already seen in some of the other newer variants, which is partly reassuring as their likely effect is to some extent more predictable.

Under the simplified naming scheme proposed by the World Health Organization, lineage B.1.525 has been labelled variant Eta.

Statistics

Cases by country (Updated as of 27 August 2021) GISAID[6]
Country Confirmed cases Last Reported Case
 Canada 1,403
 USA 1,184 11 June 2021
 Germany 738 23 June 2021
 France 686 08 June 2021
 Denmark 613 24 May 2021
 United Kingdom 517 31 May 2021
 Italy 397 22 June 2021
 Nigeria 255 21 May 2021
 India 221 31 May 2021
 Spain 174 18 June 2021
 Norway 81 09 May 2021
 Belgium 74 22 June 2021
 Ireland 71 29 May 2021
  Switzerland 55 13 June 2021
 Netherlands 54 31 May 2021
 Luxembourg 52 20 May 2021
 Slovenia 52 08 April 2021
 Turkey 47 31 March 2021
 Ghana 38 04 April 2021
 Uganda 37 12 May 2021
 South Sudan 36 03 April 2021
 Finland 25 09 April 2021
 Togo 25 25 February 2021
 Portugal 24 11 June 2021
 Bangladesh 18 15 June 2021
 Austria 17 30 April 2021
 Israel 17 18 May 2021
 Japan 17 02 June 2021
 Australia 15 31 May 2021
 Kenya 13 30 April 2021
 Malta 13 21 June 2021
 South Africa 13 26 May 2021
 Cote d'Ivoire 10 25 February 2021
 Poland 10 14 March 2021
 Singapore 10 27 April 2021
 Sweden 8 14 April 2021
 Angola 7 16 April 2021
 Cameroon 7 02 March 2021
 Niger 6 01 April 2021
 Philippines 6 24 March 2021
 Guinea 5
 Indonesia 5 05 May 2021
 Kuwait 5 05 June 2021
 Rwanda 5 28 January 2021
 Costa Rica 4 28 March 2021
 Reunion 4 25 May 2021
 Malaysia 3 27 March 2021
 Mali 3 04 April 2021
 Greece 2 09 April 2021
 Guadeloupe 2 11 March 2021
 Jordan 2 07 January 2021
 Mayotte 2 29 March 2021
 Qatar 2 15 April 2021
 Russia 2 11 May 2021
 South Korea 2 26 February 2021
 Thailand 2 01 March 2021
 Argentina 1 04 May 2021
 Belarus 1 22 March 2021
 Brazil 1 15 February 2021
 Estonia 1 29 March 2021
 Gabon 1 30 March 2021
 Gambia 1
 Latvia 1 26 April 2021
 Morocco 1 02 March 2021
 Senegal 1 11 May 2021
 Sri Lanka 1 28 April 2021
 Tunisia 1 05 March 2021
 Armenia 3 5 August 2021
 Bhutan 1
 Gibraltar 2
 Kyrgyzstan 16 17 June 2021
World (71 countries) Total: 7,129 Total as of 27 August 2021

See also

References

  1. ^ "Delta-PCR-testen" [The Delta PCR Test] (in Danish). Statens Serum Institut. February 25, 2021. Retrieved February 27, 2021.
  2. ^ a b "GISAID hCOV19 Variants (see menu option 'G/484K.V3 (B.1.525)')". GISAID. Retrieved March 4, 2021.
  3. ^ a b "Status for udvikling af SARS-CoV-2 Variants of Concern (VOC) i Danmark" [Status of development of SARS-CoV-2 Variants of Concern (VOC) in Denmark] (in Danish). Statens Serum Institut. February 27, 2021. Retrieved February 27, 2021.
  4. ^ a b "B.1.525". cov-lineages.org. Pango team. Retrieved March 22, 2021.
  5. ^ "Spike Variants: Eta variant, aka B.1.525". covdb.stanford.edu. Stanford University Coronavirus Antiviral & Resistance Database. July 1, 2021. Retrieved July 5, 2021.
  6. ^ "GISAID - hCov19 Variants". www.gisaid.org. Retrieved July 2, 2021.