CCL6

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Structures	Swiss-model
Domains	InterPro

chemokine (C-C motif) ligand 6
chemokine (C-C motif) ligand 6
Identifiers
Symbol	CCL6
Alt. symbols	SCYA6, C10, MRP-1
Chr. 11 [1]
Structures
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Structures	Swiss-model
Domains	InterPro

Chemokine (C-C motif) ligand 6 (CCL6) is a small cytokine belonging to the CC chemokine family that has only been identified in rodents.

In mice, CCL6 is expressed in cells from

myeloid origin (e.g. the immature myeloid cell lines DA3 and 32D cl3, and the macrophage cell line P388D) that can also be greatly induced in culture with GM-CSF. However, in activated T cell lines, expression of CCL6 is greatly reduced.^[1] CCL6 can also be induced in the mouse lung by the cytokine interleukin 13.^[2] Mouse CCL6 is located on chromosome 11.^[3] The cell surface receptor for CCL6 is believed to be the chemokine receptor CCR1.^[2]

References

^ Orlofsky et al. Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes. Cell Regul. 2 (5), 403-412 (1991).
^ ^a ^b Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.
^ Berger et al. The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines. DNA Cell Biol. 12 (9), 839-847 (1993)

[1] Orlofsky et al. Novel expression pattern of a new member of the MIP-1 family of cytokine-like genes. Cell Regul. 2 (5), 403-412 (1991).

[ma-2] Ma et al. The C10/CCL6 chemokine and CCR1 play critical roles in the pathogenesis of IL-13-induced inflammation and remodeling. J Immunol. 2004 Feb 1;172(3):1872-81.

[3] Berger et al. The gene for C10, a member of the beta-chemokine family, is located on mouse chromosome 11 and contains a novel second exon not found in other chemokines. DNA Cell Biol. 12 (9), 839-847 (1993)

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