IFNK
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| Location (UCSC) | Chr 9: 27.52 – 27.53 Mb | Chr 4: 35.15 – 35.15 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Interferon kappa, also known as IFN-kappa, is a protein that in humans is encoded by the IFNK gene.[5][6][7]
Function
IFN-kappa is a member of the type I interferon family. Type I interferons are a group of related glycoproteins that play an important role in host defenses against viral infections. This protein is expressed in keratinocytes and the gene is found on chromosome 9, adjacent to the type I interferon cluster.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000147896 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042993 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: interferon".
- PMID 11514542.
- PMID 12391192.
3.Antiviral activity of transiently expressed IFN-kappa is cell-associated. Buontempo, P.J., Jubin, R.G., Buontempo, C.A., Wagner, N.E., Reyes, G.R., Baroudy, B.M. J. Interferon Cytokine Res. (2006) [Pubmed]
Further reading
- Liu C, Batliwalla F, Li W, et al. (2008). "Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in rheumatoid arthritis". Mol. Med. 14 (9–10): 575–81. PMID 18615156.
- DeCarlo CA, Severini A, Edler L, et al. (2010). "IFN-κ, a novel type I IFN, is undetectable in HPV-positive human cervical keratinocytes". Lab. Invest. 90 (10): 1482–91. PMID 20479716.
- Silva LK, Blanton RE, Parrado AR, et al. (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7. PMID 20588308.
- Yang XR, Liang X, Pfeiffer RM, et al. (2010). "Associations of 9p21 variants with cutaneous malignant melanoma, nevi, and pigmentation phenotypes in melanoma-prone families with and without CDKN2A mutations". Fam. Cancer. 9 (4): 625–33. PMID 20574843.
- Ferreira RC, Pan-Hammarström Q, Graham RR, et al. (2010). "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency". Nat. Genet. 42 (9): 777–80. S2CID 205356843.
- Laaksovirta H, Peuralinna T, Schymick JC, et al. (2010). "Chromosome 9p21 in amyotrophic lateral sclerosis in Finland: a genome-wide association study". Lancet Neurol. 9 (10): 978–85. PMID 20801718.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. PMID 12975309.
- Rincon-Orozco B, Halec G, Rosenberger S, et al. (2009). "Epigenetic silencing of interferon-kappa in human papillomavirus type 16-positive cells". Cancer Res. 69 (22): 8718–25. PMID 19887612.
- Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. PMID 15164053.
- Zhang Z, Henzel WJ (2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. PMID 15340161.
- van Es MA, Veldink JH, Saris CG, et al. (2009). "Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis". Nat. Genet. 41 (10): 1083–7. S2CID 8659710.
- Harley IT, Niewold TB, Stormont RM, et al. (2010). "The role of genetic variation near interferon-kappa in systemic lupus erythematosus". J. Biomed. Biotechnol. 2010: 1–11. PMID 20706608.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.