CXCL5

Source: Wikipedia, the free encyclopedia.
CXCL5
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_002994

NM_009141

RefSeq (protein)

NP_002985

NP_033167

Location (UCSC)Chr 4: 74 – 74 MbChr 5: 90.91 – 90.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene.[5][6]

Function

The protein encoded by this gene, CXCL5 is a small

angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.[8] The gene for CXCL5 has four exons and is located on human chromosome 4 amongst several other CXC chemokine genes.[7][9] CXCL5 has been implicated in connective tissue remodelling.[8] CXCL5 has been also described to regulate neutrophil homeostasis.[10]

Clinical significance

CXCL5 plays a role in reducing sensitivity to

cystitis.".[11] CXCL5 is well known to have chemotactic and activating functions on neutrophil, mainly during acute inflammatory responses. However CXCL5 expression is also higher in atherosclerosis (a chronic inflammatory condition) but is not associated with neutrophil infiltration. Instead CXCL5 has a protective role in atherosclerosis by directly controlling macrophage foam cell formation.[12]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163735 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 7929219
    .
  6. ^ "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5".
  7. ^
    PMID 7929219
    .
  8. ^ .
  9. .
  10. .
  11. .
  12. PMID 23376791
    .

External links

Further reading

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