CXCL5
Ensembl | |||||||||
---|---|---|---|---|---|---|---|---|---|
UniProt | |||||||||
RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 4: 74 – 74 Mb | Chr 5: 90.91 – 90.91 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
C-X-C motif chemokine 5 (CXCL5 or ENA78) is a protein that in humans is encoded by the CXCL5 gene.[5][6]
Function
The protein encoded by this gene, CXCL5 is a small
angiogenic properties. It elicits these effects by interacting with the cell surface chemokine receptor CXCR2.[8] The gene for CXCL5 has four exons and is located on human chromosome 4 amongst several other CXC chemokine genes.[7][9] CXCL5 has been implicated in connective tissue remodelling.[8] CXCL5 has been also described to regulate neutrophil homeostasis.[10]
Clinical significance
CXCL5 plays a role in reducing sensitivity to
cystitis.".[11] CXCL5 is well known to have chemotactic and activating functions on neutrophil, mainly during acute inflammatory responses. However CXCL5 expression is also higher in atherosclerosis (a chronic inflammatory condition) but is not associated with neutrophil infiltration. Instead CXCL5 has a protective role in atherosclerosis by directly controlling macrophage foam cell formation.[12]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000163735 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029371 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7929219.
- ^ "Entrez Gene: CXCL5 chemokine (C-X-C motif) ligand 5".
- ^ PMID 7929219.
- ^ S2CID 2449190.
- S2CID 8087808.
- PMID 22326959.
- PMID 21734176.
- Howard Lovy (July 11, 2011). "Sunburn pain discovery could lead to better arthritis treatments". FierceBiotech. Archived from the original on 2011-07-13.
- PMID 23376791.
External links
- Human CXCL5 genome location and CXCL5 gene details page in the UCSC Genome Browser.
Further reading
- Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, Perretti M, Ahluwalia A (2007). "A novel inflammatory pathway involved in leukocyte recruitment: role for the kinin B1 receptor and the chemokine CXCL5". J. Immunol. 179 (7): 4849–56. PMID 17878384.
- Walz A, Schmutz P, Mueller C, Schnyder-Candrian S (1997). "Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease". J. Leukoc. Biol. 62 (5): 604–11. S2CID 20141618.
- Struyf S, Proost P, Van Damme J (2004). Regulation of the Immune Response by the Interaction of Chemokines and Proteases. Advances in Immunology. Vol. 81. pp. 1–44. PMID 14711052.
- Walz A, Burgener R, Car B, et al. (1992). "Structure and neutrophil-activating properties of a novel inflammatory peptide (ENA-78) with homology to interleukin 8". J. Exp. Med. 174 (6): 1355–62. PMID 1744577.
- Power CA, Furness RB, Brawand C, Wells TN (1995). "Cloning of a full-length cDNA encoding the neutrophil-activating peptide ENA-78 from human platelets". Gene. 151 (1–2): 333–4. PMID 7828901.
- Corbett MS, Schmitt I, Riess O, Walz A (1995). "Characterization of the gene for human neutrophil-activating peptide 78 (ENA-78)". Biochem. Biophys. Res. Commun. 205 (1): 612–7. PMID 7999089.
- Koch AE, Kunkel SL, Harlow LA, et al. (1994). "Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis". J. Clin. Invest. 94 (3): 1012–8. PMID 8083342.
- Power CA, Clemetson JM, Clemetson KJ, Wells TN (1996). "Chemokine and chemokine receptor mRNA expression in human platelets". Cytokine. 7 (6): 479–82. PMID 8580362.
- Ahuja SK, Murphy PM (1996). "The CXC chemokines growth-regulated oncogene (GRO) alpha, GRObeta, GROgamma, neutrophil-activating peptide-2, and epithelial cell-derived neutrophil-activating peptide-78 are potent agonists for the type B, but not the type A, human interleukin-8 receptor". J. Biol. Chem. 271 (34): 20545–50. PMID 8702798.
- Keates S, Keates AC, Mizoguchi E, et al. (1997). "Enterocytes are the primary source of the chemokine ENA-78 in normal colon and ulcerative colitis". Am. J. Physiol. 273 (1 Pt 1): G75–82. PMID 9252512.
- Wuyts A, Proost P, Lenaerts JP, et al. (1998). "Differential usage of the CXC chemokine receptors 1 and 2 by interleukin-8, granulocyte chemotactic protein-2 and epithelial-cell-derived neutrophil attractant-78". Eur. J. Biochem. 255 (1): 67–73. PMID 9692902.
- Wyrick PB, Knight ST, Paul TR, et al. (1999). "Persistent chlamydial envelope antigens in antibiotic-exposed infected cells trigger neutrophil chemotaxis". J. Infect. Dis. 179 (4): 954–66. PMID 10068592.
- Wuyts A, Govaerts C, Struyf S, et al. (1999). "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms". Eur. J. Biochem. 260 (2): 421–9. PMID 10095777.
- Hogaboam CM, Bone-Larson CL, Steinhauser ML, et al. (1999). "Novel CXCR2-dependent liver regenerative qualities of ELR-containing CXC chemokines". FASEB J. 13 (12): 1565–74. S2CID 7043800.
- Luu NT, Rainger GE, Nash GB (2000). "Differential ability of exogenous chemotactic agents to disrupt transendothelial migration of flowing neutrophils". J. Immunol. 164 (11): 5961–9. PMID 10820279.
- Crane IJ, Wallace CA, McKillop-Smith S, Forrester JV (2000). "Control of chemokine production at the blood–retina barrier". Immunology. 101 (3): 426–33. PMID 11106948.
- Zhang C, Thornton MA, Kowalska MA, et al. (2001). "Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus". Blood. 98 (3): 610–7. PMID 11468158.
- Chandrasekar B, Melby PC, Sarau HM, et al. (2003). "Chemokine-cytokine cross-talk. The ELR+ CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway". J. Biol. Chem. 278 (7): 4675–86. PMID 12468547.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMID 12477932.