IFNA13

IFNA13
Available structures
Gene ontology
Molecular function	cytokine activity; type I interferon receptor binding; cytokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	natural killer cell activation involved in immune response; B cell differentiation; defense response; B cell proliferation; blood coagulation; positive regulation of peptidyl-serine phosphorylation of STAT protein; humoral immune response; adaptive immune response; defense response to virus; type I interferon signaling pathway; response to exogenous dsRNA; T cell activation involved in immune response; cytokine-mediated signaling pathway; innate immune response; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
	ENSG00000233816
	n/a
	P01562
	n/a
	NM_006900
	n/a
	NP_076918
	n/a
	Wikidata
View/Edit Human

Interferon alpha-1/13, also known as IFN-alpha-1/13, is a protein that in humans is encoded by the IFNA1 and IFNA13 genes.^[3]^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000233816 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: interferon".
PMID 1385305
.

Further reading

Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329 (2): 295–302.
PMID 9425112
.

Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8.
S2CID 11183658
.

Weber H, Weissmann C (1983). "Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli". Nucleic Acids Res. 11 (16): 5661–9.
PMID 6310510
.

Lamesch P, Li N, Milstein S, Fan C, Hao T, Szabo G, Hu Z, Venkatesan K, Bethel G (2007). "hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes". Genomics. 89 (3): 307–15.
PMID 17207965
.

Goeddel DV, Leung DW, Dull TJ, Gross M, Lawn RM, McCandliss R, Seeburg PH, Ullrich A, Yelverton E (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6.
S2CID 1900300
.

Myers MP, Andersen JN, Cheng A, Tremblay ML, Horvath CM, Parisien JP, Salmeen A, Barford D, Tonks NK (2001). "TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B". J. Biol. Chem. 276 (51): 47771–4.
PMID 11694501
.

Hussain M, Ni D, Gill D, Liao MJ (2000). "IFN-alpha1a gene is the major variant in the North American population". J. Interferon Cytokine Res. 20 (9): 763–8.
PMID 11032395
.

Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74.
PMID 15164053
.

Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R (2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes". Pediatr. Infect. Dis. J. 28 (4): 333–5.
S2CID 25601837
.

Hardy MP, Owczarek CM, Jermiin LS, Ejdebäck M, Hertzog PJ (2004). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45.
PMID 15233997
.

Silva LK, Blanton RE, Parrado AR, Melo PS, Morato VG, Reis EA, Dias JP, Castro JM, Vasconcelos PF (2010). "Dengue hemorrhagic fever is associated with polymorphisms in JAK1". Eur. J. Hum. Genet. 18 (11): 1221–7.
PMID 20588308
.

Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, Slot Rv, Wijmenga C, Goeman JJ (2007). "Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes". J. Infect. Dis. 196 (6): 826–34.
PMID 17703412
.

Shuai K, Horvath CM, Huang LH, Qureshi SA, Cowburn D, Darnell Jr JE (1994). "Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions". Cell. 76 (5): 821–8.
S2CID 41612814
.

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7.
PMID 15489334
.

Sen GC, Lengyel P (1992). "The interferon system. A bird's eye view of its biochemistry". J. Biol. Chem. 267 (8): 5017–20.
PMID 1371992
.

Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
PMID 12477932
.

Tiefenbrun N, Melamed D, Levy N, Resnitzky D, Hoffman I, Reed SI, Kimchi A (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44.
PMID 8668211
.

Nagata S, Mantei N, Weissmann C (1980). "The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha". Nature. 287 (5781): 401–8.
S2CID 29500779
.

Todokoro K, Kioussis D, Weissmann C (1984). "Two non-allelic human interferon alpha genes with identical coding regions". EMBO J. 3 (8): 1809–12.
PMID 6479148
.

Schuurhof A, Bont L, Siezen CL, Hodemaekers H, Van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13.
S2CID 24678182
.

IFNA13 is an interferon gene.

v
t
e
Cell signaling: cytokines
By family
Chemokine
CCL

CCL1

CCL2/MCP1

CCL3/MIP1α

CCL4/MIP1β

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CCL6

CCL7

CCL8

CCL9

CCL11

CCL12

CCL13

CCL14

CCL15

CCL16

CCL17

CCL18/PARC/DCCK1/AMAC1/MIP4

CCL19

CCL20

CCL21

CCL22

CCL23

CCL24

CCL25

CCL26

CCL27

CCL28

CXCL

CXCL1/KC

CXCL2

CXCL3

CXCL4

CXCL5

CXCL6

CXCL7

CXCL8/IL8

CXCL9

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CX3CL

CX3CL1

XCL

XCL1

XCL2

TNF

TNFA

Lymphotoxin
TNFB/LTA

TNFC/LTB

TNFSF4

TNFSF5/CD40LG

TNFSF6

TNFSF7

TNFSF8

TNFSF9

TNFSF10

TNFSF11

TNFSF13

TNFSF13B

EDA

Interleukin
Type I
(grouped by
receptor
subunit)
γ chain

IL2/IL15

IL4/IL13

IL7

IL9

IL21

β chain

IL3

IL5

GMCSF

IL6 like/gp130

IL6

IL11

IL27

IL30

IL31
+non IL OSM

LIF

CNTF

CTF1

IL12 family/IL12RB1

IL12

IL23

IL27

IL35

Other

IL14

IL16

IL32

IL34

IL10 family

IL10/IL22

IL19

IL20

IL24

IL26

Interferon type III
IL28/IFNL2+3

IL29/IFNL1

Interferon
I

IFNA1

IFNA2

IFNA4

IFNA5

IFNA6

IFNA7

IFNA8

IFNA10

IFNA13

IFNA14

IFNA16

IFNA17

IFNA21

IFNB1

IFNK

IFNW1

II

IFNG

Ig superfamily

IL1A/IL1F1

IL1B/IL1F2

1Ra/IL1F3

IL1F5

IL1F6

IL1F7

IL1F8

IL1F9

IL1F10

33/IL1F11

18/IL1G

IL17 family

IL17A
)

Other

Hematopoietic

KITLG

Colony-stimulating factor

SPP1

MIF

By function/
cell

proinflammatory cytokine

IL1

TNFA

Monokine

Lymphokine
T_h1
IFNγ

TNFβ

T_h2
IL4

IL5

IL6

IL10

IL13

v
t
e

Retrieved from "https://en.wikipedia.org/w/index.php?title=IFNA13&oldid=1216139740"

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000233816 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: interferon".

[pmid1385305-4] PMID 1385305
.

[2]

[3]

[4]