CXCL16

Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small

[1] These are unusual features for a chemokine, allowing CXCL16 to be expressed as a cell surface bound molecule, as well as a soluble chemokine.^[2] CXCL16 is produced by dendritic cells found in the T cell zones of lymphoid organs, and by cells found in the red pulp of the spleen.^[1] Cells that bind and migrate in response to CXCL16 include several subsets of T cells, and natural killer T (NKT) cells.^[1]

CXCL16 interacts with the chemokine receptor

The administration of folinic acid, which forces the methylation of CXCL 16, induces high levels of methylation of the CXCL 16 gene promoter in colon, ileum and lung and causes iNKT cells accumulation in these tissues. Colonization of neonatal GF mice, but not in adult mice, with a conventional microbiota decreases hypermethylation levels of CXCL 16.[4]