CXCL13
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| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 4: 77.51 – 77.61 Mb | Chr 5: 96.1 – 96.11 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Chemokine (C-X-C motif) ligand 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) or B cell-attracting chemokine 1 (BCA-1), is a protein ligand that in humans is encoded by the CXCL13 gene.[5][6]
Function
CXCL13 is a small
gut of humans.[5] The gene for CXCL13 is located on human chromosome 4 in a cluster of other CXC chemokines.[6]
In T lymphocytes, CXCL13 expression is thought to reflect a germinal center origin of the T cell, particularly a subset of T cells called follicular B helper T cells (or TFH cells). Hence, expression of CXCL13 in T-cell lymphomas, such as angioimmunoblastic T-cell lymphoma, is thought to reflect a germinal center origin of the neoplastic T-cells.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000156234 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023078 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ PMID 9463416.
- ^ S2CID 4373691.
- PMID 11825566.
- S2CID 4369622.
- PMID 17284527.