CCL3

Source: Wikipedia, the free encyclopedia.
CCL3
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_002983

n/a

RefSeq (protein)

NP_002974

n/a

Location (UCSC)Chr 17: 36.09 – 36.09 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[3]

Function

CCL3 is a

polymorphonuclear leukocytes[4] through binding to the receptors CCR1, CCR4 and CCR5.[3]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[5][3]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human

febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[6]

Interactions

CCL3 has been shown to

Attracts macrophages, monocytes and neutrophils.

See also

References

  1. ^ a b c ENSG00000277632, ENSG00000274221 GRCh38: Ensembl release 89: ENSG00000278567, ENSG00000277632, ENSG00000274221 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b c "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
  4. PMID 3279154
    .
  5. .
  6. .
  7. .

External links

Further reading

This page is based on the copyrighted Wikipedia article: CCL3. Articles is available under the CC BY-SA 3.0 license; additional terms may apply.Privacy Policy