Myeloblast
| Myeloblast | |
|---|---|
 Myeloblast | |
| Identifiers | |
| TH | H2.00.04.3.04002 |
| FMA | 83524 |
| Anatomical terms of microanatomy | |
The myeloblast is a
cell survival.[1]
Structure
Myeloblasts reside extravascularly in the
Hematopoiesis
takes place in the extravascular cavities between the sinuses of the marrow. The wall of the sinuses is composed of two different types of cells, endothelial cells and adventitial reticular cells. The hemopoietic cells are aligned in cords or wedges between these sinuses, with myeloblasts and other granular progenitors concentrated in the subcortical regions of these hemopoietic cords.
Myeloblasts are rather small cells with a diameter between 14 and 18μm. The major part is occupied by a large oval
Mitochondria
are present but have a rather small size.
The main features that distinguish a myeloblast from a lymphoblast upon microscopic examination are the presence of cytoplasmic granules, the lesser degree of condensation in the nuclear chromatin, and the increased prominence of the nucleoli.[2]
Development
These cells descend from the primitive reticulum cells, which are found in the stroma of the
hemocytoblast. At this time several developing blood cell lines are available, like erythropoiesis and thrombopoiesis. Granulopoiesis is regulated by humoral agents, like colony-stimulating factor (CSF) and interleukin 3
.
Function
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Clinical significance
The most common problem with malfunctioning myeloblasts is
progenitor cells renew themselves and have a limited differentiated division. Sometimes acute myeloblastic leukemia can be initiated by earlier hematologic disorders, like myelodysplastic syndrome, pancytopenia, or hypoplasia of the bone marrow
.
See also
- Granulopoiesis
- Hematopoiesis
- Pluripotential hemopoietic stem cell
- Myeloid leukemia
References
- PMID 18182579.
- ISBN 978-1-4160-2973-1.
- PMID 2473799.
- PMID 9665192.
Further reading
- Wilson JD, Braunwald E, Isselbacher KJ, Martin JB, Fauci AS, Root RK (1991). Harrison's Principles of Internal Medicine (12th ed.). McGraw-Hill Inc.
- Curran RC, Crocker J (2000). Curran's Atlas of Histopathology (4th ed.). Harvey Miller Publishers Ltd., Oxford University Press Inc.
- Bloom W, Fawcett DW (1986). A Textbook of Histology (12th ed.). W.B. Saunders Company.
- Williams MJ (May 1955). "Myeloblastic leukemia preceded by prolonged hematologic disorder". Blood. 10 (5): 502–9. PMID 14363331.
- Beutler E, Lichtman M, Coller B, Kipps T (1995). Williams Hematology (5th ed.). McGraw-Hill Inc.