Puumala orthohantavirus

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Puumala orthohantavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Hantaviridae
Genus: Orthohantavirus
Species:
Puumala orthohantavirus

Puumala orthohantavirus (PUUV) is a species of

nephropathia epidemica. Puumala orthohantavirus HFRS is lethal in less than 0.5% of the cases.[1] Rarely, PUUV infection can cause Guillain–Barré syndrome.[2]

Puumala orthohantavirus was discovered and named in 1980 named after Puumala, a municipality in Finland.[3] The virus is found predominantly in Scandinavia and Finland, although it has also been reported elsewhere in Northern Europe, Poland and Russia. Because the bank vole (Myodes glareolus) acts as a reservoir for the virus, nephropathia epidemica cases track with the vole population in a three- to four-year cycle. Humans are infected through inhalation of dust from vole droppings.[4] It has been theorized that Puumala orthohantavirus, unlike other members of the genus Orthohantavirus, may also have lethal effects on its rodent host.[5]

In August 2014 an Israeli researcher studying the behavior of the bank vole in Finland died after contracting the Puumala orthohantavirus, which caused a complete breakdown of her immune system.[6]

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