Saccharopine dehydrogenase
| Saccharopine Dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| |||||||||
| saccharopine dehydrogenase (putative) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | SCCPDH | ||||||
Chr. 1 q44 | |||||||
| |||||||
In
eukaryotes and archaea
.
Function
Simplistically, SDH uses
substrate
, Saccharopine, in order to form the products, lysine and alpha-ketoglutarate.
This can be described by the following equation:[1]
- SDH
Saccharopine ⇌ lysine + alpha-ketoglutarate
Saccharopine dehydrogenase EC
polypeptide with lysine
ketoglutarate reductase (PF).
Homospermidine synthase proteins (EC). Homospermidine synthase (HSS) catalyses the synthesis of the polyamine homospermidine from 2 mol putrescine in an NAD+-dependent reaction.[3]
Structure
There appears to be two
beta-sheet surrounded by alpha-helices and loops (alpha/beta fold).[4]
Clinical significance
Deficiencies are associated with hyperlysinemia.
References
- Saccharopine+Dehydrogenases at the U.S. National Library of Medicine Medical Subject Headings (MeSH)